BNFO 300 
Molecular Biology Through Discovery
Schedule for Advisory Panels on Research Proposals
Monday, May 8, through Friday, May 12
Spring 2017 

  1. Guidance for Presenters
  2. Guidance for Panelists
  3. Schedule of Panels

A. Guidance for Presenters (see How to Prepare for a Panel for further advice)

  • Where and When: See Schedule
    Presenters should be in the room at least 5 minutes before the time of their panel. Non-presenters (and panelists) are welcome at any time.
  • Duration of presentation: Up to seven minutes and no more. At six minutes, you'll hear a courteous tinkle of a bell. At seven minutes, a bone-shaking clang will stop your presentation if it has not already concluded. If you're in the middle of a sentence, you'll be permitted to complete the sentence (with no more than one conjunction), but that's it.
  • Duration of question and answer period: Up to eight minutes, marked by a bell. Questions will be posed by the panel concerning the presentation and the written proposal.
  • Loading presentations: There won't be time to download your presentation. It must be on the computer before the panels begin. This can be done in either of two ways:
    • E-mail your presentation to me by 15 minutes before the beginning of the panel
    • Bring your presentation on a memory device by 15 minutes before the beginning of the panel

    Do not expect to download it from your e-mail or upload it on the spot from your memory device.

B. Guidance for Panelists

  • Reviewers: Each proposal has been assigned a primary reviewer and a secondary reviewer, noted in the schedule. The primary reviewer will begin the discussion after the presentation. All panelists are invited, nay, urged to join in as well.
  • Goals of the proposal: Please see How to Write a Research Proposal to see the goals presenters were asked to address. If you like, you can also take a look at an example of a proposal.
  • Goals of the presentation: Please see How to Give a Presentation Focused on an Experiment to see the goals presenters were asked to address.
  • Goals of the course: In brief, the primary goal of the course was to bring students into the scientific process of approximating truth, giving due weight to what has been observed, limited by how it was observed, and distinguishing observation from mere assertion. In not brief, see the Course Objectives.
  • Goals of the review process:

    • Please consider whether the proposal and presentation have addressed the general goals of the course. For example, a generally useful question would be "How do you know that [some assertion] is true?".
    • Please consider whether the proposal and presentation have addressed the specific goals of presentations and proposals. For example, if the proposal and presentation does not make abundantly clear that the presenter understands the principle behind the proposed experiment, you might through probing questions give the presenter an opportunity to display (or perhaps discover) such understanding. Do not presume that just because the term "Western blot" rolls confidently off the tongue that the presenter has any idea what it is.
    • Presenters are to understand at least one experiment thoroughly, but in doing so, they may not have learned a lot about other experiments. Don't fault them for not having a Plan B.
  • Feedback: The eight minutes of questioning will by itself provide valuable feedback to the presenter. You're certainly invited to provide written feedback as well if you can, but feel no guilt if you can't. Presenters have until Sunday, May 14, to revise their proposals, if they wish.
  • Thanks: Please accept them for the bracing experience you've given fledgling molecular biologists.

C. Schedule of Panels

Titles link to the written proposals (active Saturday, May 6, for Panel I and Sunday, May 7, for the other panels).
Presentation links to the corresponding powerpoint presentation (active the day of the presentation).

Panel I: Monday, May 8, 3:00 - 4:00 PM. Harris Hall Room 3112 (see map)
Panelists: John Bigbee, Greg Buck, Pat Trimmer

Alina AfzalCan Vitamin C prevent the mtDNA in the aged induced pluripotent stem cell?
Primary: John Bigbee, Secondary: Pat Trimmer       (Presentation)
Bharath PeddibhotlaRelating the structure of aggregated alpha synuclein in Parkinsonian neurons to its preferential binding on the outer mitochondrial membrane
Primary: Pat Trimmer, Secondary: Greg Buck       (Presentation)
EJ KochisDifferences in GTPase Hydrolysis rates of developmentally regulated rRNAs of Plasmodium Falciparum
Primary: Greg Buck, Secondary: Pat Trimmer       (Presentation)
Ruairidh BarlowPossible Mutation of NDUFA2 Leads to Parkinson's Disease
Primary: John Bigbee, Secondary: Greg Buck       (Presentation)

Panel II: Tuesday, May 9, 10:30 - 11:30 AM. Harris Hall Room 3112 (see map)
Panelists: Jeff Dupree, Jennifer Koblinski, Larisa Litovchick

Amanda LuongIdentifying the Protein Interactions Responsible for LIN52 Degradation
Primary: Larisa Litovchick, Secondary: Jennifer Koblinski       (Presentation)
Peter SamuelCitrulline coupled with Arsenic Trioxide as a potential inducer of the PERK/eIF2-alpha apoptotic pathway in GBM cells
Primary: Jennifer Koblinski, Secondary: Jeff Dupree       (Presentation)
Neha SehgalActivation of the Ryanodine Receptor (UNC-68) and the Success of Neuronal Regeneration
Primary: Jeff Dupree, Secondary: Jennifer Koblinski       (Presentation)
Lasya GundlapudiLeukocyte Migration through the Blood Brain Barrier       (text version)
Primary: Larisa Litovchick, Secondary: Jeff Dupree       (Presentation)

Panel III: Tuesday, May 9, 2:15 - 3:15 PM. Harris Hall Room 3112 (see map)
Panelists: Wan-Ling Chiu, Tony Faber, Andrei Ivanov

Fadi HijazMeasurement of Changes in Force Generation of Cardiomyocytes through the Down Regulation of Vinculin using CRISPR-Cas Gene Editing
Primary: Andrei Ivanov, Secondary: Tony Faber       (Presentation)
Aarthi PrakashFurin-Enhanced In Vivo Production of Factor IX
Primary: Tony Faber, Secondary: Wan-Ling Chiu       (Presentation)
Neel GohilThe Role of phospholipase-C beta-1 in intracellular calcium release in smooth muscle contraction
Primary: Andrei Ivanov, Secondary: Wan-Ling Chiu       (Presentation)
Alex LeathCharacterization of tRNA Modification Patterns in a Recoded Organism
Primary: Wan-Ling Chiu, Secondary: Tony Faber       (Presentation)

Panel IV: Wednesday, May 10, 1:00 - 2:00 PM. Harris Hall Room 3112 (see map)
Panelists: Sarah Rothschild, Rita Shiang, Greg Walsh,

Josh FungTbx5 Dominant Negative Protein Inhibiting Myocardial Regeneration in Zebrafish
Primary: Greg Walsh, Secondary: Rita Shiang       (Presentation)
Deeksha JainMutations in MCL-1 PEST Region of Breast Cancer on Binding Affinity to Bak/Bax
Primary: Rita Shiang, Secondary: Sarah Rothschild       (Presentation)
Kaivalya DandamudiMeasurement of the p38 signaling pathway in the Pro253Arg mutation of FGFR2 in regulation of bone development in Apert Syndrome      (original version)
Primary: Sarah Rothschild, Secondary: Greg Walsh       (Presentation)

Panel V: Thursday, May 11, 9:30 - 10:30 AM. West Grace South Room 1004a (far northeast side of building; see map)
Panelists: Jane Roberts, Tricia Smith, Stefano Toldo

Ankita ThakurTreating Ischemia and Reperfusion Injury by Inhibiting AIM2 in order to restore function of Cardiomyocytes
Primary: Jane Roberts, Secondary: Stefano Toldo       (Presentation)
Erin CochranCannabinoid receptor interacting protein 1a (CRIP1a) effect on CB1 inverse agonists
Primary: Stefano Toldo, Secondary: Tricia Smith       (Presentation)
Jared MannDownregulation of Sox2 with CBD via AMPK
Primary: Tricia Smith, Secondary: Stefano Toldo       (Presentation)
Danny RayesDefining Epidermal Growth Factor Receptor exon 20 mutant sensitivity to tyrosine kinase inhibition
Primary: Jane Roberts, Secondary: Tricia Smith       (Presentation)

Panel VI: Thursday, May 11, 11:00 - 12:00 noon. Harris Hall Room 3112 (see map)
Panelists: Gail Christie, Allison Johnson, Peter Uetz

Bethany YachuwAntirepressor identification in Bacillus bacteriophage phiCM3
Primary: Allison Johnson, Secondary: Gail Christie       (Presentation)
Jacob JaminetDetermination of sugar uptake in Saccharomyces
Primary: Peter Uetz, Secondary: Allison Johnson       (Presentation)
Nikhita PuthuveetilThe effect of duplication of the variable region stem loops on sfRNA virulence in the dengue virus
Primary: Gail Christie, Secondary: Peter Uetz       (Presentation)

Panel VII: Friday, May 12, 9:15 - 10:15 AM. Harris Hall Room 3112 (see map)
Panelists: Bill Barton, Glen Kellogg, Darrell Peterson

Jesse RaynorComparison of Exemplars of Rotamer Clusters Across the Proteinogenic Amino Acids
Primary: Bill Barton, Secondary: Glen Kellogg       (Presentation)
Thomas RaymondDetermination of Short, Amyloid Beta Derived Peptides Which Inhibit Binding of Amyloid Beta to Apolipoprotein E
Primary: Glen Kellogg, Secondary: Darrell Peterson       (Presentation)
Diana MarquezImplementing CRISPR Type III-B in human cell to target RNA encoded viruses
Primary: Darrell Peterson, Secondary: Glen Kellogg       (Presentation)
E AlqaffasInfluenza a, and the process of inhibiting its binding
Primary: Bill Barton, Secondary: Darrell Peterson       (Presentation)

Panel VIII: Friday, May 12, 10:30 - 11:30 AM. Harris Hall Room 3112 (see map)
Panelists: Andrew Davies, Javier Maeso, Carmen Sato-Bigbee

Amanda AtrashDisruption of DISC1 via knockdown of NDEL1 stunts dendritic spine structure in the hippocampus region of mice
Primary: Javier Maeso, Secondary: Andrew Davies       (Presentation)
Kevin LimlengcoElimination of Microglial Cells in Adult Mice using Cre/Lox Recombinase      (original version)
Primary: Carmen Sato-Bigbee, Secondary: Andrew Davies       (Presentation)
Teja KatravulapalliInvestigating regulation of aging by transcription factors DAF 16 and SKN-1 in the IIS pathway of C Elegans
Primary: Andrew Davies, Secondary: Javier Maeso       (Presentation)
Colin HawkesConsequences to the axon initial segment after near total removal of microglia in healthy CNS and in mice suffering recent CNS injury
Primary: Carmen Sato-Bigbee, Secondary: Javier Maeso       (Presentation)

Panel IX: Friday, May 12, 11:45 - 12:45 PM. Harris Hall Room 3112 (see map)
Panelists: Jim Lister, Carmen Sato-Bigbee, Fernando Tenjo

Lucas Rizkalla PDK1 Inhibition and Possible Induction of a Mesenchymal-Epithelial Transition as a Curative Measure in Proliferating Cancer Cells
Primary: Fernando Tenjo, Secondary: Jim Lister       (Presentation)
Ryan DuongUnderstanding the involvement of NRAP protein in the dystrophin complex of myocytes
Primary: Jim Lister, Secondary: Carmen Sato-Bigbee       (Presentation)
Rachel MillerBlockage of the S1PR1 receptor using S1P modulator Fingolomid on T cells compared to the silencing of MicroRNA miR-155
Primary: Carmen Sato-Bigbee, Secondary: Fernando Tenjo       (Presentation)