BNFO 300 
Molecular Biology Through Discovery
Questionnaire on: Belozersky & Spirin (1957) - The world before mRNA
(please press SUBMIT button when finished)
Spring 2017  


I. Basic Information

A. Your name  
II. Old business
  1. Summary of an experiment described in a research article and Critiques
    Clear on how to write a summary, how to critique someone else's, and how to submit them through the BNFO300 summary blog?


     
  2. Crick et al (1961) and the triplet code
    Drawing, perhaps, on the companion to Crick (1961) and Problem Set 5, Questions 5 and 6, do you understand how Crick et al's experiment worked? Any concerns about mutagenesis by acridines? Recombination between two phages? The nature of suppressor mutations? How to construct multiply mutant phages? What the double and triple mutants say about the genetic code?

     
  3. Jones & Nirenberg (1962) and Alien Genetic Code
    Drawing, perhaps, on the companion to Jones & Nirenberg (1962), do you understand Jones & Nirenberg's experiment worked? The nature of RNA produced by polynucleotide phosphorylase? Interpretation of Table 3? How do deduce an alien genetic code?

     
  4. Research proposal?
    Progress? Problems?

III. Belozersky & Spirin (1957)

  1. How far have you gotten in this article (and its companion)?)?
         

  2. Consider how comfortable you are with the following topics regarding these matters:
     
    • The one-gene - one-ribosome - one-protein model (Fig. 2 of the companion)
       
    • Volkin and Astrachan's result
       
    • How to read the table of Belozersky & Spirin
       
    • How to calculate (G+T) / (A+C) etc
       
    • The relationship of Belozersky & Spirin's results to the 1-gene 1-ribosome 1-protein model
       
         
IV. Miscellaneous
Any other comments, questions, suggestions, or concerns you may have?
(nb. Issues concerning your proposal are always welcome)

Thanks!

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