BNFO 300 
Molecular Biology Through Discovery
Questionnaire on: Crick et al (1961) & Jones and Nirenberg (1961) - Nature of the Genetic Code
(please press SUBMIT button when finished)
Fall 2014  


I. Basic Information

A. Your name 
II. Old business
(no need to repeat anything you've said in a previous questionnaire)
  1. Summary of an experiment described in a research article
    Clear on the why, what, and how, of writing a summary?     And how to critique someone else's?

     
  2. Crick et al (1961) and the triplet code
    Regarding the companion to Crick (1961), any concerns about mutagenesis by acridines? Recombination between two phages? The nature of suppressor mutations? How to construct multiply mutant phages? What the double and triple mutants say about the genetic code?

     
  3. Research proposal?
    Progress? Problems?

III. Jones & Nirenberg (1962) Survey of RNA codewords

A. How far have you gotten in Jones & Nirenberg (1962) (and its companion)? The Alien Genetic Code simulation?
     

B. Consider how comfortable you are with the following topics regarding these matters:

  • The overall goal of the work by Nirenberg and others
     
  • The specific focus of Jones & Nirenberg (1961)
     
  • The nature of the experiment
     
  • The nature of RNA produced by polynucleotide phosphorylase
     
  • Theoretical expectations of experiment J108, Table 3
     
  • Interpretation of Table 3
     
  • How in principle to deduce the alien genetic code
     
  • How to use Alien Genetic Code within BioBIKE
     

C. Choose up to five study questions that you would most like discussed in class and explain why.
     

IV. Miscellaneous

Any other comments, questions, suggestions, or concerns you may have?

Thanks!

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