Modified 7/31/2000
NETWORKS IN NATURE:SOME REFLECTIONS ON TIME, SPACE AND THE EMERGENCE OF LIVING SYSTEMS
PPT Slide
MY GIANTS:
WHO IS THAT MASKED SCIENTIST?
SOME MORE REFERENCES
ROUGH OUTLINE OF TALK
THE MODELING RELATION: THE ESSENCE OF SCIENCE
THE MODELING RELATION
THE NEWTONIAN MODEL
MORE ON THE MODELING RELATION
NATURAL VS FORMAL SYSTEMS
COMPLEXITY
COMPLEXITY VS COMPLICATION
NETWORKS IN NATURE
THERMODYNAMICS OF OPEN SYSTEMS
THE NATURE OF THERMODYNAMIC REASONING
SOME CONSEQUENCES
EXAMPLES:
HOW CAN LIFE FIGHT ENTROPY?
DISSIPATION AND THE SECOND LAW OF THERMODYNAMICS
PHENOMENOLOGICAL DESCRIPTION OF A SYTEM
A GENERALISATION FOR ALL LINEAR FLOW PROCESSES
A SUMMARY OF ALL LINEAR FLOW PROCESSES
COUPLED PROCESSES
STATIONARY STATES AWAY FROM EQUILIBRIUM AND THE SECOND LAW OF THERMODYNAMICS
STATIONARY STATES AWAY FROM EQUILIBRIUM
HOMEOSTASIS IS LIKE A STEADY STATE AWAY FROM EQUILIBRIUM
IT HAS A CIRCUIT ANALOG
THE RESTING CELL
EQUILIBRIUM RESULTS FROM ISOLATING THE SYSTEM
WHAT ARE THERMODYNAMIC NETWORKS?
ELECTRICAL NETWORKS ARE THERMODYNAMIC
MOST DYNAMIC PHYSIOLOGICAL PROCESSES ARE ANALOGS OF ELECTRICAL PROCESSES
COUPLED PROCESSES HAVE A NATURAL REPRESENTATION AS MULTI-PORT NETWORKS
REACTION KINETICS AND THERMODYNAMIC NETWORKS
EXAMPLE: ATP SYNTHESIS IN MITOCHONDRIA
EXAMPLE: ATP SYNTHESIS IN MITOCHONDRIA-NETWORK I
IN THE REFERENCE STATE IT IS SIMPLY NETWORK II
THE SAME KINETIC SYSTEM HAS AT LEAST TWO NETWORK REPRESENTATIONS, BOTH VALID
A LESSON FROM CHAOTICS
THE DOUBLE SCROLL TIMECOURSE
THE DOUBLE SCROLL ATTRACTOR
SOME PUBLISHED NETWORK MODELS OF PHYSIOLOGICAL SYSTEMS
ARTIFICIAL NEURAL NETWORKS
NEURAL NETWORKS ARE SPECIAL CASES OF SIGNALLING NETWORKS IN CELLULAR SYSTEMS
GENERALIZING NEURAL NETWORKS TO MODEL CELL SIGNALLING: D. BRAY
GENERALIZING NEURAL NETWORKS TO MODEL CELL SIGNALLING: JEFF PRIDEAUX , JOY WARE
EMERGENT PROPERTIES OF NETWORKS OF BIOLOGICAL SIGNALING PATHWAYS, BY U.S. BHALLA AND R. IYENGAR
EMERGENT PROPERTIES OBSERVED
PROBLEMS:
OTHER RELATED FORMALISMS
RELATIONAL NETWORKS
LIFE ITSELF
Email: mikuleck@hsc.vcu.edu
Home Page: http://views.vcu.edu/~mikuleck/