Lab Members






VCU Biology






Uetz Lab Publications

For selected publications see Home or PubMed. For metrics see Google Scholar. If you do not have access to the linked papers, please email me at uetz@vcu.edu


• Babu, M. [29 authors] Greenblatt, J.F., Saier, M., Uetz, P., Moraes, T., Parkinson, J. and Emili, A. (2018) Global Landscape of Membrane Protein Complexes in Escherichia coli. Nature Biotechnology, 36 (1): 103-112.

• Wuchty S, SA Mueller, JH Caufield, R Häuser, P Aloy, S Kalkhof, P Uetz (2018) Proteome data improves protein function prediction in the interactome of H. pylori. Mol. Cell. Prot., 17 (5): 961-973

• Rodionova, I.; Mohan Babu, Andrew Emili, Norman Goodacre, Peter Uetz
& Milton Saier (2018) The nitrogen regulatory PII protein (GlnB) and N-acetyl-glucosamine 6-phosphate epimerase (NanE) allosterically activate glucosamine 6-phosphate deaminase (NagB) in Escherichia coli. Journal of Bacteriology, Feb 7;200(5). pii: e00691-17. doi: 10.1128/JB.00691-17

• Uetz, P., Mehla, J., K. Sinner, F. Oesterheld, K. Richter, D. Schubert, C. Urbanke (2018) Protein-protein interactions, in Lottspeich, F. (ed.), Bioanalytics, Wiley, pp. 381-417

* Uetz, P. & Pohl, E. (2018) Protein-Protein and Protein-DNA Interactions. In: Wink, M. (ed.), Introduction to Molecular Biotechnology, 3rd ed. Wiley-VCH, in press.

• Mehla J., Caufield JH & Uetz P. (2018) Making the Right Choice: Critical Parameters of the Y2H Systems. In: Oñate-Sánchez (ed.), Two-Hybrid Systems. Methods and Protocols, Methods in Molecular Biology, 1794: 17-28

• Uetz, P. & Stylianou, A. (2018) The original descriptions of reptiles and their subspecies. Zootaxa 4375: 257-264.


• Mehla J. et al. (2017) Virus-host protein-protein interactions of mycobacteriophage Giles. Sci. Reports, 7: 16514.

• Babu, M. [29 authors] Greenblatt, J.F., Saier, M., Uetz, P., Moraes, T., Parkinson, J. and Emili, A. (2017) Global Landscape of Membrane Protein Complexes in Escherichia coli. Nature Biotechnology, published online 27 Nov 2017.

• Berjón-Otero M, Lechuga A, Mehla J, Uetz P, Salas M, Redrejo-Rodríguez M. (2017) Bam35 tectivirus intraviral interaction map unveils new function and localization of phage ORFan proteins. J Virol. 2017 Jul 26. pii: JVI.00870-17. doi: 10.1128/JVI.00870-17

• Wuchty S, Rajagopala SV, Blazie SM, Parrish JR, Khuri S, Finley RL Jr, Uetz P (2017) The Protein Interactome of Streptococcus pneumoniae and Bacterial Meta-interactomes Improve Function Predictions. mSystems. 2017 Jun 6;2(3). pii: e00019-17. doi: 10.1128/mSystems.00019-17.

• Rodionova IA, Zhang Z, Mehla J, Goodacre N, Babu M, Emili A, Uetz P, Saier MH Jr (2017) The phosphocarrier protein HPr of the bacterial phosphotransferase system globally regulates energy metabolism by directly interacting with multiple enzymes in Escherichia coli. J Biol Chem. 2017 Jun 20. pii: jbc.M117.795294. doi: 10.1074/jbc.M117.795294

Uetz, P. & Garg, A. (2017) Correspondence: Increasing disconnect between species and DNA sequences. Nature 545(7655):412

Caufield JH, Wimble C, Shary S, Wuchty S & Uetz P (2017) Bacterial Protein Meta-Interactomes Predict Cross-Species Interactions and Protein Function. BMC Bioinformatics 18(1):171. doi: 10.1186/s12859-017-1585-0.

Roll U; [33 other authors], Uetz P, Wagner P, Wang Y, Orme CDL, Grenyer R and Meiri S (2017) The global distribution of tetrapods reveals a need for targeted reptile conservation. Nature Ecol. Evol., DOI: 10.1038/s41559-017-0332-2

Sakharwalkar, N.; Caufield, J.H. & Uetz, P. (2017) Two‐hybrid and Related Systems. Encyclopedia of Life Sciences, John Wiley & Sons, eLS. 1–9, DOI: 10.1002/9780470015902.a0000981.pub2

Mehla J, Caufield JH, Sakhawalkar N & Uetz P (2017) A comparison of two hybrid approaches for detecting protein-protein interactions. Methods in Enzymology586:333-358. doi: 10.1016/bs.mie.2016.10.020

• Meiri S; Bauer AM, Allison A, Castro-Herrera F, Chirio L, Colli G, Das I, Doan TM, Glaw F, Grismer LL, Hoogmoed M, Kraus F, LeBreton M, Meirte D, Nagy ZT, C. Nogueira C de, Oliver P, Pauwels OSG, Pincheira-Donoso D, Shea G, Sindaco R, Tallowin OJS, Torres-Carvajal O, Trape JF, Uetz P, Wagner P, Wang Y, Ziegler T, and Roll U (2017) Extinct, obscure or imaginary: the lizard species with the smallest ranges. Diversity and Distributions, DOI: 10.1111/ddi.12678

• Šmek P, Uetz P & Pavón-Vázquez CJ (2017) Range extension of Mesoscincus managuae (Dunn, 1933) in Guatemala. Mesoamerican Herpetology 4 (4): 955-958


• Mariano R., Khuri S., Uetz P. & Wuchty S. (2016) Local Action with Global Impact: Highly Similar Infection Patterns of Human Viruses and Bacteriophages. mSystems 1 (2): e00030-15. doi:10.1128/mSystems.00030-15.

• Mariano R., Wuchty S, Vizoso-Pinto M. Häuser R. & Uetz P. & . (2016) The interactome of Streptococcus pneumoniae and its bacteriophages show highly specific patterns of interactions among bacteria and their phages. Scientific Reports 6:24597. doi: 10.1038/srep24597.

• Goodacre N, Edwards N, Danielsen M, Uetz P, Wu C (2016) Predicting nsSNPs that disrupt protein-protein interactions using docking. IEEE/ACM Trans Comput Biol. Bioinform., 14 pp.

Uetz P (2016) The Reptile Database at 20. Herpetological Review 47 (2), 330-334.


• Caufield JH, Wimble C, Abreu M & Uetz P (2015) Protein complexes in bacteria. Plos. Comp. Biol., 27;11(2):e1004107. doi: 10.1371/journal.pcbi.1004107.

• Mehla J, Dedrick RM, Caufield JH, Siefring R, Mair M, Johnson A, Hatfull GF, Uetz P. (2015) The protein interactome of mycobacteriophage Giles predicts functions for unknown proteins. J Bacteriol. 2015 May 18. pii: JB.00164-15.

• Müller SA, Pernitzsch SR, Haange SB, Uetz P, von Bergen M, Sharma CM, Kalkhof S. (2015) Stable isotope labeling by amino acids in cell culture based proteomics reveals differences in protein abundances between spiral and coccoid forms of the gastric pathogen Helicobacter pylori. J Proteomics. 2015 May 12. pii: S1874-3919(15)30009-9. doi: 10.1016/j.jprot.2015.05.011

• Osterman A; Stellberger T; Gebhardt A; Kurz, Friedel CC; Uetz P, Nitschko H; Baiker A; Vizoso-Pinto MG (2015) The Hepatitis E virus intraviral interactome. Scientific Reports 5: 13872,

• Mehla, J., J. H. Caufield, & Uetz P. (2015) Mapping Protein–Protein Interactions Using Yeast Two-Hybrid Assays. Cold Spring Harb Protoc. 2015 May 1;2015(5):pdb.prot086157. doi: 10.1101/pdb.prot086157.

• Mehla, J., J. H. Caufield, & Uetz P. (2015) The Yeast Two Hybrid system: A tool for mapping protein-protein interactions. Cold Spring Harb Protoc. 2015 May 1;2015(5):pdb.top083345. doi: 10.1101/pdb.top083345.

• Feldman, A; Bauer, A; Herrera-Castro, F; Chirio, L; Das, I; Doan, T; Maza, E; Meirte, D; de Campos-Nogueira, C; Nagy, Z; Torres-Carvajal, O; Uetz, P; Meiri, S (2015) The geography of snake reproductive mode. Global Ecology and Biogeography 24 (12): 1433–1442


PNAS title

• Rajagopala, SV, Sikorski P, Kumar A, Mosca R, Vlasblom J, Arnold R,  Franca-Koh J, Pakala SB, Phanse S, Ceol A, Häuser R, Siszler G, Wuchty S, Emili A, Babu M, Aloy P, Pieper R and Uetz P (2014) The binary protein-protein interaction landscape of Escherichia coli. Nature Biotechnology, 32, 285–290 [Sequence (Supplement): pGBGT7g]

• Häuser R, Ceol A, Rajagopala SV, Mosca R, Siszler G, Wermke N, Sikorski P, Schwarz F, Schick M, Wuchty S, Aloy P, Uetz P. (2014) A Second-generation Protein-Protein Interaction Network of Helicobacter pylori. Mol Cell Proteomics 13(5):1318-29

• Wagemans J, Blasdel BG, Van den Bossche A, Uytterhoeven B, De Smet J, Paeshuyse J, Cenens W, Aertsen A, Uetz P, Delattre AS, Ceyssens PJ, Lavigne R. (2014) Functional elucidation of antibacterial phage ORFans targeting Pseudomonas aeruginosa. Cell Microbiol. 16 (12): 1822-35. doi: 10.1111/cmi.12330.

• Kolker E, Özdemir V, Martens L, Hancock W, Anderson G, Anderson N, Aynacioglu S, Baranova A, Campagna SR, Chen R, Choiniere J, Dearth SP, Feng WC, Ferguson L, Fox G, Frishman D, Grossman R, Heath A, Higdon R, Hutz MH, Janko I, Jiang L, Joshi S, Kel A, Kemnitz JW, Kohane IS, Kolker N, Lancet D, Lee E, Li W, Lisitsa A, Llerena A, Macnealy-Koch C, Marshall JC, Masuzzo P, May A, Mias G, Monroe M, Montague E, Mooney S, Nesvizhskii A, Noronha S, Omenn G, Rajasimha H, Ramamoorthy P, Sheehan J, Smarr L, Smith CV, Smith T, Snyder M, Rapole S, Srivastava S, Stanberry L, Stewart E, Toppo S, Uetz P, Verheggen K, Voy BH, Warnich L, Wilhelm SW, Yandl G. (2014) Toward more transparent and reproducible omics studies through a common metadata checklist and data publications. OMICS. 2014 Jan;18(1):10-4. doi: 10.1089/omi.2013.0149.

• Wuchty, S. & Uetz, P. (2014) Protein Interaction Networks of E. coli and S. cerevisiae are similar. Scientific Reports 4: 7187 doi:10.1038/srep07187.

• Chibucos M.C., Zweifel A.E., Herrera J.C., Meza W., Eslamfam S., Uetz P., Siegele D. A., Hu J.C., and Giglio M.G. (2014) An ontology for microbial phenotypes. BMC Microbiology 14 (1): 294, doi:10.1186/s12866-014-0294-3

* Blasche S, Arens S, Ceol A, Siszler G, Schmidt MA, Häuser R, Schwarz F, Wuchty S, Aloy P, Uetz P*, Stradal T & Koegl M (2014) The EHEC-host interactome reveals novel targets for the translocated intimin receptor. Scientific Reports 4 (7531): 1-11, doi:10.1038/srep07531 (* corresp. author)

• Scharf I, Feldman A, Novosolov M, Pincheira-Donoso D, Das I, Böhm M, Uetz P, Torres-Carvajal O, Bauer AM, Roll U& Meiri S (2014) Late bloomers and baby boomers: an analysis of ecological drivers of squamate longevity. Global Ecology and Biogeography, published online

• Uetz P; Davison R; Ellis J (2014) Book review: Wallach, V. et al. (2014) Snakes of the World: A Catalogue of Livingand Extinct Species. Herp. Rev. 45 (4): 721-722.


PNAS title

• Blasche, S., Mörtl, M., Steuber, H., Siszler, G., Nisa, S., Schwarz, F., Lavrik, I., Maskos, K., Donnenberg, M.S., Ullmann, D., Uetz*, P. & Kögl, M. (2013) The E. coli effector protein NleF is a caspase inhibitor. Plos One, 8(3): e58937. (*corresponding author).

• Blasche S, Wuchty S, Rajagopala SV, Uetz P. (2013) The Protein Interaction Network of Bacteriophage Lambda with Its Host, Escherichia coli. J Virol. 2013 Dec;87(23):12745-55

• Goodacre, N.F., Gerloff, D.L. & Uetz, P. (2013) Protein domains of unknown function (DUFs) are essential in bacteria. mBio 5 (1): e00744-13. doi:10.1128/mBio.00744-13 (published online 31 Dec 2013 but appearing in Jan/Feb 2014 issue of mBio)

• Hardisty, A., Roberts, D. and The Biodiversity Informatics Community [including Uetz, P.] (2013) A decadal view of biodiversity informatics: challenges and priorities. BMC Ecology. 13:16

• Castoe,Todd A.; A. P. Jason de Koning, Kathryn T. Hall, Daren C. Card, Drew R. Schield, Matthew K. Fujita, Robert P. Ruggiero, Jack F. Degner, Juan M. Daza, Wanjun Gu, Jacobo Reyes-Velasco, Kyle J. Shaney, Jill M. Castoe, Samuel E. Fox, Alex W. Poole, Daniel Polanco, Jason Dobry, Michael W. Vandewege, Qing Li, Ryan K. Schott, Aurélie Kapusta, Patrick Minx, Cédric Feschotte, Peter Uetz, David A. Ray, Federico G. Hoffmann, Robert Bogden, Eric N. Smith, Belinda S. W. Chang, Freek J. Vonk, Nicholas R. Casewell, Christiaan V. Henkel, Michael K. Richardson, Stephen P. Mackessy, Anne M. Bronikowsi, Mark Yandell, Wesley C. Warren, Stephen M. Secor, and David D. Pollock (2013) The Burmese python genome reveals the molecular basis for extreme adaptation in snakes. PNAS, Dec 2, 2013, doi:10.1073/pnas.1314475110.

• Meiri, Shai; Aaron M. Bauer, Laurent Chirio, Guarino R. Colli, Indraneil Das, Tiffany M. Doan, Anat Feldman, Fernando-Castro Herrera, Maria Novosolov, Panayiotis Pafilis, Daniel Pincheira-Donoso, Gary Powney, Omar Torres-Carvajal, Peter Uetz, & Raoul Van Damme (2013) Are lizards feeling the heat? A tale of ecology and evolution under two temperatures. Global Ecology and Biogeography 22: 834–845

• Pincheira-Donoso, D.; Bauer, A.M.; Meiri, S.; Uetz, P. (2013) Global taxonomic diversity in living reptiles. Plos One, 8(3): e59741. doi:10.1371/journal.pone.0059741.

Uetz, P. (2013) in: Li Vigni, Fabrizio: A Life for Reptiles and Amphibians. Volume 1. A collection of 55 interviews on «How to become a Herpetologist». Chimaira Books, 496 pp.


Lottspeich Bioanalytik

• Häuser, R. et al. (2012) RsfA (YbeB) proteins are conserved ribosomal silencing factors. Plos Genetics 8(7): e1002815. doi:10.1371/journal.pgen.1002815

• Häuser, R., Stellberger, T., Rajagopala, S.V. & Uetz, P. (2012) Matrix-Based Yeast Two-Hybrid Screen Strategies and comparison of systems. In: Suter, B. (ed.) Yeast Two-Hybrid and related technologies. Methods Mol Biol. 812: 1-20.

Uetz, P., Bürckstümmer, T., Sinner, E.-K. Urbanke, C. & Oesterhelt, F. (2012) Protein-Protein-Wechselwirkungen. In: Lottspeich, F. & Engels, J.W. (eds.) Bioanalytik, 3. Aufl., Spektrum-Verlag, Heidelberg, pp. 425-458

• Appletans, W., Vanhoorne, B., Decock, W., Paulay, G., [115 aphabetically listed authors including Uetz, P.], Wilson, S.P., Hernandez, F., Mees, J. & Costello, M.J. (2012) The Magnitude of Global Marine Species Diversity. Current Biology 22(23):2189-2202.

• Häuser, R., Stellberger, T., Rajagopala, S.V. & Uetz, P. (2012) Array-Based Yeast Two-Hybrid Screens: A Practical Guide. In: Suter, B. (ed.) Yeast Two-Hybrid and related technologies. Methods Mol Biol. 812: 21-38.

• Stellberger, T., Häuser, R., Uetz, P. & von Brunn, A. (2012) Yeast Two-Hybrid Screens: Improvement of array-based screening results by N- and C-terminally tagged fusion proteins. In: Klinger, C. (ed.), Functional Genomics, second edition. Methods Mol Biol. 815: 277-88.

• Orchard, Sandra; Samuel Kerrien, Sara Abbani, Bruno Aranda, Jignesh Bhate, Shelby Bidwell, Alan Bridge, Leonardo Briganti, Fiona Brinkman, Gianni Cesareni, Andrew Chatr-aryamontri, Emilie Chautard0,, Carol Chen, Marine Dumousseau, David Eisenberg, Johannes Goll, Robert Hancock, Linda I Hannick, Igor Jurisica, Jyoti Khadake, David J Lynn, Usha Mahadevan, Livia Perfetto, Arathi Raghunath, Sylvie Ricard-Blum, Bernd Roechert, Lukasz Salwinski, Volker Stümpflen, Mike Tyers, Peter Uetz, Ioannis Xenarios, & Henning Hermjakob (2012) Protein interaction data curation: the International Molecular Exchange (IMEX) consortium. Nature Methods 9 (4): 345–350.

• Häuser, R., Blasche, S., Haggård, E., Dokland, T., Salas, M., Casjens, S., Molineux, I. and Uetz, P. (2012) Protein-protein interactions of bacteriophage. Advances in Virus Research 83B: 219-298.

• Rajagopala, S.V.; Sikorski, P.; Caufield, J.H.; Tovchigrechko, A. & Uetz, P. (2012) Studying protein complexes by the yeast two-hybrid system. Methods, published online.

• Caufield JH, Sakhawalkar N, Uetz P. (2012) A comparison and optimization of yeast two-hybrid systems. Methods. 2012 Dec 8. doi:pii: S1046-2023(12)00302-7. 10.1016/j.ymeth.2012.12.001

Uetz, P. (2012) Editorial for "The Yeast two-hybrid system". Methods 58 (4): 315-316

• Uetz, P. (2012) Book review: Beolens, B. et al. 2011, The eponym dictionary of reptiles. Johns Hopkins University Press. Herp. Rev. 43 (1): 159–160

• Uetz, P. (2012) Book review: POSCHADEL, J.R. & PLATH, M. (2012): Genetik für Terrarianer - Grundlagen und Anwendungen. Sauria 34 (4): 58-59


Network Biology

• Sabri, M., Häuser, R., Ouellette, M., Liu, J., Dehbi, M., Moeck, G., García, E., Titz, B., Uetz*, P. & Moineau*, S. (2011) Genome annotation and intra-viral interactome of the Streptococcus pneumoniae virulent phage Dp-1. J. Bact. 193 (2): 551-562. [* joint corresponding]

• Häuser, R., Sabri, M., Moineau, S. & Uetz, P. (2011) The proteome and interactome of Streptococcus pneumoniae phage Cp1. J. Bact. 193 (12): 3135–3138.

• Rajagopala, S.V. , Casjens, S. & Uetz, P. (2011) The protein interaction map of bacteriophage lambda. BMC Microbiology, 11:213

• Castoe, T.A., A.P. Jason de Koning, K.T. Hall, K. D. Yokoyama, W. Gu, E. N. Smith, C. Feschotte, P. Uetz, D. A Ray, J. Dobry, R. Bogden, S. P. Mackessy, A. M. Bronikowski, W. C. Warren, S. M. Secor and D. D Pollock (2011) Sequencing the genome of the Burmese python (Python molurus bivittatus) as a model for studying extreme adaptations in snakes. Genome Biology 12:406

• Rasmussen, A.R., Murphy, J.C., Ompi, M., Gibbons, J.W. & Uetz, P. (2011) Marine Reptiles. PLoS ONE 6(11): e27373

• Uetz P. & Pohl E. (2011) Protein-DNA und Protein-Protein-Interaktionen. In: Wink, M. (ed.), Molekulare Biotechnologie, 2. Aufl., Wiley-VCH, pp. 269-284

• Uetz P. & Pohl E. (2011) Protein-DNA and Protein-Protein Interactions. In: Wink, M. (ed.), Introduction to Molecular Biotechnology, 2nd ed. Wiley-VCH, pp. 257-271

• Rajagopala, S.V. & Uetz, P. (2011) Analysis of Protein–Protein Interactions Using High-throughput Yeast Two-Hybrid Screens. In: G. Cagney & A. Emili (eds.), Network Biology. Methods in Molecular Biology 781: pp. 1-29

• Uetz, P. (2011) Book review: Largen, M. & Spawls, S. (2010): The Amphibians and Rep tiles of Ethiopia and Eritrea. Sauria 2011 (1): 25-26

• Uetz, P. (2011) Book Review: Murthy, T.S.N (2010): The Reptile Fauna of India. Sauria 2011 (2): 63


Buchanan Networks

• Stellberger, T., Häuser, R., Baiker, A., Pothineni, V.R., Haas, J. & Uetz, P. (2010) Improving the yeast two-hybrid system with permutated fusions proteins: The Varicella Zoster Virus interactome. Proteome Science, 8: 8. [doi:10.1186/1477-5956-8-8

Genbank: pGBKCg: FJ696409, pGADCg: FJ696408

Unpublished sequences: pGBKT7g, pGADT7g

• Rajagopala, S.V.; Yamamoto, N., Zweifel, A.E., Nakamichi, T., Huang, H.K., Mendez-Rios, J.D., Franca-Koh, J., Boorgula, M.P., Hu, J.C., Wanner, B.L., Mori, H. & Uetz, P. (2010) The E. coli K-12 ORFeome: a resource for comparative microbiology. BMC Genomics 11:470.

• Chen, Y.C., Rajagopala, S.V., Stellberger, T. & Uetz, P. (2010) Exhaustive Benchmarking of yeast two-hybrid systems. Nature Methods 7 (9): 667-668

• Mendez-Rios, J. & Uetz, P. (2010) Global approaches to study protein-protein interactions among viruses and hosts. Future Microbiology 5: 289-301.

Uetz, P.; Titz, B.; Rajagopala, S.V. & Cagney, G. (2010) Experimental methods for protein interaction identification and characterization. In: Buchanan, M. et al. (eds.) Networks in the Cell, Cambridge University Press, pp. 53-82

Uetz, P. (2010) The original descriptions of reptiles. Zootaxa 2334: 59–68.



• Fossum E., Baiker A., Friedel C.C., Suthram S., Rajagopala S.V., Titz B., Schmidt T., Kraus T., Bandyopadhyay S., Rose D., Uhlmann M., Zeretzke C., Dong Y.A., Boulet H., Bailer S., Koszinowski U., Ideker T., Uetz P., Zimmer R. & Haas J. (2009) Evolution and divergence of herpesviral protein interaction networks. PloS Pathogens 5 (9): 00570. [doi:10.1371/journal.ppat.1000570]

• Rajagopala, S.V.; Hughes, K.T. & Uetz, P. (2009) Benchmarking yeast two-hybrid systems using the interactions of bacterial motility proteins. Proteomics, 9: 5296–5302.

• Rajagopala S.V. & Uetz P. (2009) Analysis of yeast proteome using the large-scale yeast two-hybrid system. In: Stagljar, I. (ed.) Methods in Molecular Biology, Yeast Functional Genomics and Proteomics, Humana Press, vol. 548: 223-246.

• Giglio, M., Mungall, C., Uetz, P., Yin, L., Goll, J., Siegele, D., Chibucos, M., and Hu, J. (2009) Development of an Ontology of Microbial Phenotypes (OMP). Nature Precedings


Panchenko • Koegl, M. & Uetz, P. (2008) Improving yeast two-hybrid systems. Briefings in Functional Genomics and Proteomics 6(4):302-12

• Uetz P., Titz B. & Cagney G. (2008) Experimental methods for protein interaction identification and characterization. In: Przytycka, T. & Panchenko, A., Protein-protein interactions and networks: identification, characterization and prediction.

Titz B., Rajagopala S.V., Häuser R., Goll J., Wohlbold K., McKevitt M.T., Palzkill T. & Uetz P. (2008) The Binary Protein Interactome of Treponema pallidum - the Syphilis Spirochete. PloS ONE 3(5): e2292. doi:10.1371/journal.pone.0002292

Goll, J.; Rajagopala, S.V.; Shiau, S.C.; Wu, H.; Lamb, B.T. & Uetz, P. (2008) MPIDB: the microbial protein interaction database. Bioinformatics 24: 1743-1744

Rajagopala SV, J Goll, NDD Gowda, KC Sunil, B Titz, A Mukherjee, SS Mary, N Raviswaran, CS Poojari, S Ramachandra, S Shtivelband, SM Blazie, J Hofmann, P Uetz (2008) MPI-LIT: A literature-curated dataset of microbial binary protein-protein interactions. Bioinformatics 24 (22): 2622–2627

Ester, C. & Uetz, P. (2008) The FF domains of yeast U1 snRNP protein Prp40 mediate interactions with Luc7 and Snu71. BMC Biochemistry 9: 29


Lengauer book

Original Research

• Titz B., Häuser R., Engelbrecher A. & Uetz P. (2007) The Escherichia coli protein YjjG is a House-Cleaning Nucleotidase in vivo. FEMS Microbiology Letters, 270 (1): 49-57.

• Rajagopala S.V., Titz B., Goll J., Parish J., McKevitt M.T., Palzkill T., Finley R.L. Jr. & Uetz P. (2007) The protein network of bacterial motility. Molecular Systems Biology 3: 128

• Orchard S, Salwinski L, Kerrien S, Montecchi-Palazzi L, Oesterheld M, Stümpflen V, Ceol A, Chatr-aryamontri A, Armstrong J, Woollard P, Salama JJ, Moore S, Wojcik J, Bader GD, Vidal M, Cusick ME, Gerstein M, Gavin AC, Superti-Furga G, Greenblatt J, Bader J, Uetz P, Tyers M, Legrain P, Fields S, Mulder N, Gilson M, Niepmann M, Burgoon L, De Las Rivas J, Prieto C, Perreau VM, Hogue C, Mewes HW, Apweiler R, Xenarios I, Eisenberg D, Cesareni G, Hermjakob H. (2007) The minimum information required for reporting a molecular interaction experiment (MIMIx). Nat Biotechnol. 25 (8):894-8

Invited book chapters:

• Rajagopala S.V.; Titz B. & Uetz P. (2007) Array-based yeast two-hybrid screening for protein-protein interactions. In: Yeast Gene Analysis 2nd Edition. Methods in Microbiology Series, Vol 36, Edited by Mike Stark and Ian Stansfield, Elsevier, pp. 139-163.

• Goll J. & Uetz P. (2007) Analyzing protein interaction networks. In: T.Lengauer (ed.), Bioinformatics - From Genomes to Drugs, Vol. 3, VCH-Wiley, pp. 1121-1177.


Original Research

• Uetz, P., Y.-A. Dong, C. Zeretzke, C. Atzler, A. Baiker, B. Berger, S.V. Rajagopala, M. Roupelieva, D. Rose, E. Fossum & J. Haas (2005) Herpesviral Protein Networks and Their Interaction with the Human Proteome. Science 311: 239-242

• Titz, B., Thomas, S., Rajagopala, S.V., Chiba, T., Ito, T. & Uetz, P. (2006) Transcriptional activators in yeast. Nucleic Acids Res. 34 (3): 955-967

• Titz, B., Rajagopala, S.V., Ester, C., Häuser, R. & Uetz, P. (2006) A novel conserved assembly factor of the bacterial flagellum. J. Bacteriol. 188: 7700-7706


Invited Reviews

• Goll, J. & Uetz, P. (2006) The elusive yeast interactome. Genome Biology 7 (214): 1-6

• Uetz, P. & Stagljar, I. (2006) The interactome of human EGF/ErbB receptors. Molecular Systems Biology, doi:10.1038/msb4100048.

• Uetz, P. & Pohl, E. (2006) Protein-Protein and Protein-DNA Interactions [proofs, 1.5 MB!]. In: Wink, M. (ed.) Introduction to Molecular Biotechnology, Wiley-VCH, pp. 365-386

• Uetz, P., Sinner, E.-K., Schubert, D., Urbanke, C. (2006) Protein-Protein-Wechselwirkungen: Das two-hybrid-System und andere Methoden. Kapitel 16 in Lottspeich, F. & Engels, J.W., Bioanalytik, 2. Aufl., Spektrum/Elsevier, pp. 373-404.

• Uetz, P. & Vollert, C.S. (2006) Protein-Protein Interactions. Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine (ERGPMM), Springer Verlag, Part 16: 1548-1552

• Vollert, C.S. & Uetz, P. (2006) The Two-hybrid System. Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine (ERGPMM), Springer Verlag, Part 20: 1945-1949.


Original Research

• Uetz, P., Y.-A. Dong, C. Zeretzke, C. Atzler, A. Baiker, B. Berger, S.V. Rajagopala, M. Roupelieva, D. Rose, E. Fossum & J. Haas (2005) Herpesviral Protein Networks and Their Interaction with the Human Proteome. ScienceExpress (published online Dec. 8. 2005)

• Sharan,R., Suthram,S., Kelley,R.M., Kuhn,T., McCuine,S., Uetz,P. Sittler,T., Karp, R.M. and Ideker,T. (2005) Conserved Patterns of Protein Interaction in Multiple Species. Proc. Natl. Acad. Sci. 102: 1974-1979.


Invited Reviews

• Uetz, P. & Finley, R.L. Jr. (2005) From protein networks to biological systems. FEBS Lett., 579: 1821-1827.

• Serebriskii, I.; Golemis, E. & Uetz, P. (2005) The yeast two-hybrid system for detecting interacting proteins. In: Walker, J.M. (ed.) The Proteomics Handbook, Humana Press, Totowa (NJ), pp. 653-682.

• Uetz, P. & Grigoriev, A. (2005) The yeast interactome [2.9 MB!]. In Jorde, L.B., Little, P.F.R., Dunn, M.J. and Subramaniam, S. (Eds), Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. John Wiley & Sons Ltd: Chichester, volume 5, pp. 2033-2051.

• Ideker,T. & Tan, K. & Uetz, P. (2005) Visualization and integration of protein-protein interactions. In: Golemis,E. (ed.) Protein-Protein Interactions - A Molecular Cloning Manual, 2nd ed. Cold Spring Harbor Laboratory Press, pp. 839-856.

related stuff:



Original Research

• Vollert, C.S. & Uetz, P. (2004) The PX domain protein interaction network in yeast. Molecular and Cellular Proteomics 3: 1053-1064.

• Antoniacci, L.M., Kenna, M.A., Uetz, P., Fields, S. & Skibbens, R.V. (2004) The spindle pole body assembly component Mps3p/Nep98p functions in sister chromatid cohesion. J. Biol. Chem. 279: 49542-49550.

• Wilkinson, C.R.M., Dittmar, G.A.G.; Ohi, M.D., Uetz, P., Jones, N. and Finley, D. (2004) Ubiquitin-like Protein Hub1 is Required for pre-mRNA Splicing and Localization of an Essential Splicing Factor in Fission Yeast. Current Biology 14 (24): 2283-2288


Invited Reviews

• Uetz, P. & Pankratz, M. (2004) Protein interaction maps on the fly. Nature Biotechnology 22 (1): 43-44

• Titz, B., Schlesner, M. & Uetz, P. (2004) What do we learn from high-throughput protein interaction data and networks? Expert Reviews in Proteomics 1 (1): 89-99

• Uetz, P., Rajagopala, S.V., Dong, Y.-A. & Haas, J. (2004) From ORFeomes to protein interaction maps in viruses. Genome Res. 14: 2029-2033

• Uetz, P. & Pohl, E. (2004) Protein-Protein- und Protein-DNA-Interaktionen [1.8 MB!]. In: Wink, M. (ed.) Molekulare Biotechnologie, Wiley-VCH, pp. 385-407.

related stuff:


• Guo M, Aston C, Burchett SA, Dyke C, Fields S, Rajarao SJR, Uetz P, Wang Y, Young K & Dohlman HG (2003) The yeast G protein alpha subunit Gpa1 transmits a signal through a novel effector polyribosomal protein Scp160. Molecular Cell 12: 517-524.

related stuff:

• Hazbun, T.R. et al. (2003) Assigning function to yeast proteins by integration of technologies. Molecular Cell 12: 1353-1365 (note and data).



• Burchett SA, Flanary P, Aston CW, Jiang L, Young KH, Uetz P, Fields S and Dohlman HG (2002) Regulation of Stress Response Signaling by the N-terminal DEP (dishevelled/ EGL-10/pleckstrin) domain of Sst2, a Regulator of G Protein Signaling in Saccharomyces cerevisiae. J. Biol. Chem. 277 (25): 22156-22167

• Uetz,P., Ideker,T. & Schwikowski,B. (2002) Visualization and integration of protein-protein interactions [ 1.4 MB]. In: Golemis,E. (ed.) Protein-Protein Interactions - A Molecular Cloning Manual. Cold Spring Harbor Laboratory Press, pp. 623-646

• Uetz,P. (2002) Protein-Protein-Interaktionen im Modell Hefe. Bioforum 25 (1-2): 11-13

• Uetz,P. (2002) Protein-Protein Interactions in Yeast [uncorrected proofs]. Bioforum International 6 (3): 157-159

• Uetz,P. (2002) Proteomik: Proteine im (Hefe-) Kontext. FZK-Nachrichten 34 (1): 55-60

  related stuff:



• Tucker,C.L., Gera, J.F. & Uetz,P. (2001) Towards an understanding of complex protein interaction maps. Trends in Cell Biology 11 (23): 102-106

• Cagney,G. & Uetz,P. (2001) High-throughput two-hybrid screening using yeast arrays. Current Protocols in Protein Science 19.6: 1-13

• Cagney,G., Uetz,P. & Fields, S. (2001) Functional genomic analysis of the Saccharomyces cerevisiae 26S proteasome. Physiological Genomics 7: 27-34

• Uetz,P. (2001) Two-Hybrid Arrays. Current Opinion in Chemical Biology 6: 57-62 [published online on Dec. 19, 2001; in print in the February 2002 issue]

 related stuff:



• Uetz,P. et al. (2000) A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403: 623-627

• Uetz,P. & Hughes,R. (2000) Systematic and large-scale two-hybrid screens. Curr. Opinion in Microbiol. 3 (3): 304-309

• Cagney,G., Uetz,P. & Fields,S. (2000) High-throughput screening for protein-protein interactions using the two-hybrid assay. Meth. Enzymol. 328: 3-14


• Schwikowski,B., Uetz,P. & Fields,S. (2000) A network of interacting proteins in yeast. Nature Biotechnology 18 (12): 1257-1261

Supplemental data

...and, more herpetology papers