Welcome to Tri Nguyen’ s site

Virginia Commonwealth University, Medical College of Virginia, Department of Hematology/Oncology

Research Interests

PUBLICATIONS

Rahmani M, Davis EM, Crabtree TR, Habibi JR, Nguyen TK, Dent P, Grant S. The kinase inhibitor Sorafenib induces cell death through a process involving induction of ER Stress. Mol Cell Biol. 2007 Jun 4.

Rahmani M, Nguyen TK, Dent P, Grant S. The multikinase inhibitor Sorafenib induces apoptosis in highly imatinib mesylate-resistant Bcr/Abl⁺ human leukemia cells in association with STAT5 inhibition and Mcl-1 down-regulation. Mol Pharmacol. 2007 Jun 26.

Nguyen TK, Rahmani M, Harada H, Dent P, Grant S. MEK1/2 inhibitors sensitize BCR/ABL+ human leukemia cells to the dual ABL/SRC inhibitor BMS354825. Blood. 2007 May 1;109(9):4006-15

Nguyen TK, Rahmani M, Gao N, Kramer L, Corbin AS, Druker BJ, Dent P, Grant S. Synergistic interactions between DMAG and mitogen-activated protein kinase kinase 1/2 inhibitors in Bcr/abl+ leukemia cells sensitive and resistant to imatinib mesylate. Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2239-47

Dasmahapatra G*, Nguyen TK*, Dent P, Grant S. Adaphostin and bortezomib induce oxidative injury and apoptosis in imatinib mesylate-resistant hematopoietic cells expressing mutant forms of Bcr/Abl. Leuk Res. 2006;30:1263-1272. *These authors contributed equally to this work.

Phan TX, Hoang AV, Huynh VM, Nguyen KT, Nguyen TB, Huynh N, Pham QT, Tran VB, Tokunaga K, Sato Y. Unique secondary chromosomal abnormalities are frequently found in the chronic phase of chronic myeloid leukemia in southern Vietnam. Cancer Genet Cytogenet. 2006;168:59-68

Tri NK, Xinh PT, Nagao H, Izumi T, Ozawa K, Toyoda A, Hattori M, Sakaki Y, Tokunaga K, Sato Y. Identification of the breakpoints at 1p36.2 and 3p21.3 in an AML(M3) patient who had t(1;3)(p36.2;p21.3) at the third relapse. Genes Chromosomes Cancer. 2002;35:365-367

Xinh PT, Tri NK, Nagao H, Nakazato H, Taketazu F, Fujisawa S, Yagasaki F, Chen YZ, Hayashi Y, Toyoda A, Hattori M, Sakaki Y, Tokunaga K, Sato Y. Breakpoints at 1p36.3 in three MDS/AML(M4) patients with t(1;3)(p36;q21) occur in the first intron and in the 5' region of MEL1. Genes Chromosomes Cancer. 2003;36:313-316

Iijima Y, Okuda K, Tojo A, Tri NK, Setoyama M, Sakaki Y, Asano S, Tokunaga K, Kruh GD, Sato Y. Transformation of Ba/F3 cells and Rat-1 cells by ETV6/ARG. Oncogene. 2002;21:4374-4383

 

PATENT

Generation of human imatinib mesylate-resistant CML cell line (K562) expressing the T315I mutation (K562/T315I); VCU Invention No: 06-02, US License: pending

 

PUBLISHED ABSTRACTS

MEK1/2 inhibitors sensitize BCR/ABL+ human leukemia cells to the dual ABL/SRC inhibitor BMS354825. AACR Meeting Abstracts, Apr 2007; 2007: 5745

The multi-kinase inhibitor Sorafenib interacts synergistically with the HDAC inhibitor Vorinostat to induce apoptosis in CML cells in association with downregulation of MCL-1 and p21^CIP1. AACR Meeting Abstracts, Apr 2007; 2007: 2485.

Synergistic interactions between the Hsp-90 antagonist DMAG and MEK1/2 inhibitors in Bcr/abl⁺ leukemia cells sensitive and resistant to Imatinib mesylate. AACR Meeting Abstracts, Apr 2006; 2006: 316.

The multikinase inhibitor Sorafenib induces apoptosis in highly imatinib mesylate-resistant Bcr/Abl⁺ human leukemia cells in association with STAT5 inhibition and Mcl-1 down-regulation. AACR Meeting Abstracts, Apr 2007; 2007: 5427.

Establishment of a imatinib-resistant Philadelphia positive acute lymphoblastic leukemia cell line presenting mutation of T315I. The Japanese Society of hematology 65^th, Aug 28-31th 2003, Osaka, Japan.

Molecular and cytogenetics study in patients with chronic myeloid leukemia in southern Vietnam. The Japanese society of Hematology 64^th, Sep 12-15^th 2002, Yokohama, Japan.

Establishment, characterization, identification of the breakpoint of a novel human immature megakaryocyte cell line, HIG. Japanese society of Hematology 64^th, Sep 12-15^th 2002, Yokohama, Japan.

· From October 2004: Postdoctoral position at Hematology/Oncology Division, MCV, Virginia Commonwealth University.

· October 2000 to April 2004: Ph.D
     Human Genetics Dept- School of International Health- University of Tokyo
     International Medical Center of Japan          

· 1997-2000: Outpatient Dept of Child Nutrition Center.

· 1991-1997: M.D; University of Training Center of HCM City.