39. Chattopadhyay, Pratibhash; Gupta, Ram B. Supercritical CO₂ Based Production of Magnetically Responsive Micro- And Nanoparticles For Drug Targeting., Ind. Eng. Chem. Res., (2002), 41(24), 6049-6058.

Abstract

Magnetically responsive, controlled-release drug formulations are needed for targeted drug delivery, esp. for toxic drugs. A supercrit. antisolvent (SAS) technique is used to produce magnetically responsive poly(Me methacrylate), 50/50 poly(DL-lactide-co-glycolide), and Eudragit RS polymer particles via copptn. of the polymer with a suspension of magnetite particles in mineral oil and a fatty acid surfactant, by using dichloromethane as the solvent. The SAS technique is again used to ppt. drug-loaded magnetically responsive polymer particles. A modification of the SAS process, the SAS-EM (enhanced mass transfer) technique developed at Auburn University, is used to produce magnetite-encapsulated polymer nanoparticles of controllable sizes. In SAS-EM, atomization and increased mixing within the supercrit. phase is brought about by using a surface vibrating at an ultrasonic frequency. Size, morphol., and drug-release kinetics of the obtained particles are studied.

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