17. Kumar, Rajesh; Betageri, Guru V.; Gupta, Ram B.. Phase behavior of mixtures containing antibiotics. Effect of hydrogen bonding on tetracycline partitioning. Fluid Phase Equilib. (1998), 143(1-2), 99-109.

Abstract

Phase equil. behavior of antibiotics is important in drug design and for optimization of the recovery process in manufg. Aq./org. partitioning behavior of a clin. important antibiotic, tetracycline is measured. The org. phase includes pure solvents n-hexane, chloroform, di-Et ether and Et acetate. Measurements are also made for mixed org. phase composed of n-hexane + Et acetate. Org.-phase partitioning increases with the hydrogen bonding tendency of the solvent in the order n-hexane < chloroform < di-Et ether < Et acetate. An activity coeff. model that includes hydrogen bonding, UNIQUAC-HB (R.B. Gupta et al, 1997) is used to model the partitioning behavior between aq. and org. phases. Single solvent-org.-phase data are correlated using the model to obtain the free-energy-of-hydrogen-bonding parameters for hydrogen bonding between antibiotic and solvent. Predictions made for mixed-solvent-org.-phase systems agree well with the exptl. data without using any adjustable parameter.

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