01. Gupta, Ram B.; Heidemann, Robert A. Solubility models for amino acids and antibiotics. AIChE J. (1990), 36(3), 333-41.

Abstract

An approach is presented for modeling the effects of temp. and pH on the soly. of amino acids in water. The amino acids studied are alanine, a-aminobutyric acid, glycine, hydroxyproline, proline, serine, threonine, and valine. The data employed are activity coeffs. and solubilities of the amino acids in neutral water and the dissocn. consts. for the various amino acid ionization reactions. Activity coeffs. are correlated with the modified UNIFAC group contribution model and with new glycine and proline groups being introduced. A similar approach is presented for modeling the solubilities of certain antibiotics in mixed nonaq. solvents. Fusion temp. data and solubilities of the antibiotics in pure org. solvents are used to deduce modified UNIFAC energy interaction parameters between new large antibiotic groups and the std. alkane, alc., arom., and ester groups.

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