Mechanical ventilation is needed in patients whose respiratory systems fails to achieve gas exchange function. However, mechanical ventilation itself gives rise to lung inflammation. In order to decrease ventilator-induced inflammation, we are developing and experimentally validating an age dependent multi-scale mathematical model for ventilated lung. In this talk we will discuss the multi-scale implementation of this model and preliminary results from the organ, tissue and cellular level models.
Multi-scale modeling of ventilator-induced lung inflammation
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