This talk will discuss two models for brain dynamics and ways in which high-throughput observations constrain them. The first is a model for the gamma rhythm found in active regions of cortex. There is a wide range of possible models that generate plausible rhythms in the gamma range (30-50 Hz), but genomic data severely constrain the set of possible models, and clearly favors one family of models over another popular family. The second is a model for the delta rhythm in anesthetized or sleeping cortex. For this simpler situation we attempt to model both intrinsic regional oscillations and communication between cortical regions. We show that one plausible mechanism for intrinsic oscillations does in fact fit the data well, and we estimate some of the effective connectivity between different cortical regions.
Two models for brain dynamics and data that constrain them
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