Qibing's Homepage


Qibing Zhou, Ph. D.
Assistant Professor
Department of Chemistry
Virginia Commonwealth University
Richmond, VA 23284
Tel: (804) 828-3520
Fax: (804) 828-8599


Research Interest

Qibing's Homepage
  • Terpene Quinone Methide Derivatives as Antitumor Drugs.

  • Target DNA promoted duplex alkylating Agents.

Funded by The Thomas F. and Kate Miller Jeffress Memorial Trust

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  1. Qibing Zhou,* Lin Zhang, Miguel A. Zuniga, Robert M. Tombes, and Jennifer K. Stewart "Mixed Inhibition of P450 3A4 as a Chemoprotective Mechanism against Aflatoxin B1-induced Cytotoxicity with cis-Terpenones" Chem. Res. Toxicol. 2008, 21, 732-738.

  2. Qibing Zhou,* Ting Xu and John B. Mangrum "Selective N1-Alkylation of 2’-Deoxyguanosine with a Quinolinyl Quinone Methide" Chem. Res. Toxicol. 2007, 20, 1069-1071.

  3. Jifeng Dai and Qibing Zhou* “A Convenient Synthesis of an N-(1-Alkoxyl-9-fluorenyl)serine Acridine Conjugate” Synth. Comm. 2007, 37, 129-135.

  4. Qibing Zhou,* Hang Xie, Lin Zhang, Jennifer K. Stewart, Xing-Xing Gu, and John J. Ryan "cis-Terpenones as an Effective Chemopreventive Agent against Aflatoxin B1 Induced Cytotoxicity and TCDD-induced P450 1A/B activity in HepG2 Cells." Chem. Res. Toxicol. 2006, 19, 1415-1419.

  5. Miguel A. Zuniga, Jifeng Dai, Mark P. Wehunt and Qibing Zhou* "DNA Oxidative Damage by  Catechol Analogs of Terpene Quinone Methides in the Presence of Cu (II) and/or NADH" Chem. Res. Toxicol. 2006, 19, 828-836.

  6. Qibing Zhou* and Miguel A. Zuniga, M. A. "Quinone Methide Formations in the Cu2+-induced Oxidation of A Diterpenone Catechol and Concurrent Damage on DNA " Chem. Res. Toxicol. 2005, 18, 382-388.

  7. Kumar, D.; Veldhuyzen, W. F.; Zhou, Q.; Rokita, S. E. “Conjugation of a Hairpin Pyrrole-Imidazole Polyamide to a Quinone Methide for Control of DNA Cross-Linking” Bioconjugate Chem. 2004, 15, 915-922.

  8. Zhou, Q.; Rokita, S. E. “A General Strategy for Target-Promoted Alkylation in Biological Systems” Proc. Natl. Acad. Sci. 2003, 26, 15452-15457.  (Chemical & Engineering News)

  9. Zhou, Q.; Pande, P.; Johnson, A. E.; Rokita, S. E. “Sequence-specific delivery of a quinone methide intermediate to the major groove of DNA” Bioorg. Med. Chem. 2001, 9, 2347-2354.

  10. Zhou, Q.; Turnbull, K. D. “Quinone Methide Phosphodiester Alkylation under Aqueous Conditions” J. Org. Chem. 2001, 66, 7072-7077.

  11. Zhou, Q.; Turnbull, K. D. “Trapping Phosphodiester-Quinone Methide Adducts through in Situ Lactonization”  J. Org. Chem. 2000, 65, 2022-2029. 

  12. Zhou, Q.; Turnbull, K. D. “Phosphodiester Alkylation with a Quinone Methide” J. Org. Chem. 1999, 64, 2847-2851.

  13. O’Sullivan, M. C; Zhou, Q.; Li, Z.; Durham, T. B.; Rattendi, D.; Lane, S.; Bacchi, C. J. “Polyamine Derivatives as Inhibitors of Trypanothione Reductase and Assessment of their Trypanocidal Activities” Bioorg. & Med. Chem. 1997, 5, 2145-2155.  

  14. O’Sullivan, M. C.; Dalrymple, D. M.; Zhou, Q. “Inhibiting Effects of Spermidine Derivatives on Trypanosoma Cruzi Trypanothione Reductase” J. Enzyme Inhibition 1996, 97-114.

  15. O’Sullivan, M. C.; Zhou, Q. “Novel Polyamine Derivatives as Potent Competitive Inhibitors of Trypanosoma Cruzi Trypanothione Reductase” Bioorg. Med. Chem. Lett. 1995, 1957-1960.

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