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Professor Phone: (804) 827-6264 Fax: (804) 828-0150 |
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Professor Phone: (804) 827-6264 Fax: (804) 828-0150 |
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Oral Streptococcal Fitness And Virulence Gene By Systems Biology
This is a NIH-funded project for 5 years to
study oral streptococci related infective endocarditis (IE). By
screen the comprehensive gene deletion mutants of
Streptococcus sanguinis, we will collect as many as possible
virulence genes that involve in infection endocarditis. A Rabbit
IE animal model will be used to collect virulence factors in
vitro. Blood, serum and saliva will be used to collect virulence
factor ex vivo. Systems biology approach will be used to study
virulence factors to understand the virulence mechanism as a
whole. This combination of in-depth and breadth research will
provide an unprecedented understanding of the pathogenesis of
S. sanguinis in IE. The immediate goal of the project is to
discover virulence-related genes in S. sanguinis, and identify
key virulence factors through network analysis. The long-term
goal of this research is to establish strategies for the
prevention of streptococcal IE.
Collaborator:
Dr. Huizhi Wang
