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Professor Phone: (804) 827-6264 Fax: (804) 828-0150 |
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Professor Phone: (804) 827-6264 Fax: (804) 828-0150 |
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Systems Biology In Streptococcal Biofilm
Oral biofilm is important for periodontal diseases in which pioneers provide substrates allowing colonization of subsequent pathogens. Oral bacterial interactions, especially coaggregations between pioneering colonizers (such as mitis group streptococci, MGS) and pathogenic species (such as Porphyromonas gingivalis or Fusobacterium nucleatum), are important for periodontal diseases. A comprehensive S. sanguinis deletion mutant library has been created that including 2048 mutants. We have identified a S. sanguinis two-component system (TCS) gene that is responsible for increased adherence with P. gingivalis and F. nucleatum. We will screen the inclusive set mutants for biofilm genes. Biofilm genes will be studied in network by association of genomics, transcriptomics, metabolomics and proteomics data as we did previously for essential genes identification. The associations of biofilm genes in S. sanguinis will be studied in the gene network using systems biology approach.
Collaborator:
fu
