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Professor Phone: (804) 827-6264 Fax: (804) 828-0150 |
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Professor Phone: (804) 827-6264 Fax: (804) 828-0150 |
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Systems Biology for Essential Gene Identification and Antibacterial Drug Development
Essential genes are indispensable genes for organisms to grow and reproduce progeny under certain environment. A living organism will die before generating progeny without essential gene function. There are three types of EG that depend on the living organism and the surrounding environments includeing absoultely essential genes, conditional essential genes and development essential genes. Our current genome-wide essential gene identification inindicated that essential genes associated with genetic information processing, cell envelope and energy producing. Based on our finding, we built ePath (https://www.pubapps.vcu.edu/epath/), an essential gene database for >4000 bacterial speceis.
These essential genes will become potential targets for antibacterial drug development. Furthermore, as emerging of many antibiotic resistant bacteria recently, the identification of all essential genes in pathogens will provide new strategies to control infective diseases.
