An Opinionated Guide to Microarray Data Analysis
Department of Biostatistics
Virginia Commonwealth University
N.B. This site is under construction.
If you don't find what you want please check back in a few months.
In the mean time, suggestions for topics to be included are welcome!
This site is meant to be a companion to an article in PLoS Comp. Bio. to appear
In the mean time here are some resources:
Slides from the 2008 ISMB Tutorial on Microarray Data Analysis
Handout from the 2008 ISMB Tutorial on Microarray Data Analysis
and the older version of this Guide
This site discusses methods to address the important practical issues in microarray
data analysis, based on my experience with hundreds of data sets
and on discussions with other microarray statisticians.
The focus here is not on sophisticated algorithms but on practical issues that most researchers
encounter in the course of a microarray study. As the title suggests, this guide will give
direct advice rather than making cautious suggestions typical of the scientific literature.
This site is organized as follows
Normalization: making raw data comparable
Summarization: getting the best estimates when each feature has several probes
Selecting Genes: significance tests for individual genes or loci
Solexa data analysis New!
Comments and questions to
Jiayi Hou (Normalization)
Mercer Thorp (Image analysis)