THE CURRAN-MACINTOSH MODEL
The compartments labeled "A" and "C" are of the
same composition (isotonic).
The analogies with the intestinal epithelium:
Compartment A: Gut lumen
Compartment B: Interstitial Space
Compartment C: Blood
Tight Membrane: Tight junction
Loose Membrane: Basement Membrane
Hypodermic: Sodium-potassium ATPase
pumping sodium from cell to interstitial Space
The holistic explanation (Fidleman & Mikulecky).
In parallel with the classical mechanism (pericellular) is a transcellular mechanism:
Tight Membrane: Basolateral Cell Membrane
Loose Membrane: Apical Cell Membrane
Hypodermic: Sodium-potassium ATPase pumping sodium from cell to interstitial Space