Selected papers on computer simulations using SPICE

Thomas, S.R. and D.C. Mikulecky: Network Thermodynamic Modelling of Transepithelial Salt and Water Flow: The Kidney Proximal Tubule. Am. J. Physiol. 235: F638-F648 (l978).

Mikulecky, D.C., E.G. Huf and S.R. Thomas: A Network Thermodynamic Approach to Compartmental Analysis: Na+ Transients in Frog Skin. Biophys. J. 25:87-106 (1979).

Mikulecky, D.C.: The Use of a Circuit Simulation Program (SPICE2) to Model the Microcirculation. Proc. 2nd Mid-Atlantic Conf. on Biofluid Mechanics. Vol. 2: 327-345. Plenum Press, N.Y. (1980). (Daniel J. Schneck, ed.)

Wyatt, J.L., Jr., Mikulecky, D.C. and DeSimone, J.A., Network Modeling of Reaction- diffusion System and Their Numerical Solution Using SPICE2, Chem. Eng. Sci. 35: 2115- 2128 (1980).

Oken, D.E., S.R. Thomas and D.C. Mikulecky: A Network Thermodynamic Model of Glomerular Dynamics: Application in the Rat. Kidney Int. 19: 359-373 (1981).

Mikulecky, D.C. and J.J. Feher: The Relation Between Local and Global Transport Parameters in an Epithelial Membrane Having an Asymmetric Transport Mechanism. J. theor. Biol. 88: 575-588 (1981).

White, J.C. and D.C. Mikulecky: Application of Network Thermodynamics to the Computer Modeling of the Pharmacology of Anticancer Agents: A Network Model for Methotrexate Action as a Comprehensive Example. Pharmacology and Therapeutics 15:251-291 (1982).

Thakker, K.M., J. H. Wood and D. C. Mikulecky: Dynamic Simulation of Pharmacokinetic Systems Using the Electrical Circuit Analysis Program SPICE2. Comput. Prog. Biomed 15, 61-72 (1982).

May, J. M. and D. C. Mikulecky: The Simple Model of Adipocyte Hexose Transport: Kinetic Features, Effect of Insulin, and Network Thermodynamic Computer Simulations. J. Biol. Chem. 257: 11601-11608 (1982).

Mikulecky, D. C.: The Use of Network Thermodynamic Simulation to Calculate the Profiles of Ions, Reaction Substrates and Products, and Electrical Potential Across Membranes. in Biological Structures and Coupled Flows, proceedings of the Aaron Katzir- Katchalsky Memorial Symposium (A. Oplatka and M. Balaban ed). Academic Press, N.Y. and Balaban Int'l. Science Services, Philadelphia, (1983), pp. 61-77.

Mikulecky, D.C.: A Network Thermodynamic Approach to the Hill-King and Altman Approach to Kinetics: Computer Simulation. In: Membrane Biophysics II: Physical Methods in the Study of Epithelia (M. Dinno A.B. Calahan and T.C. Rozzell eds.) A.R. Liss, N.Y. (1983) pp 257-282.

May, J.M. and D.C. Mikulecky: Glucose Utilization in Rat Adipocytes: The Interactionof Transport and Metabolism as Affected by Insulin. J. Biol. Chem. 258:4771-4777 (1983).

Huf, E.G. and D.C. Mikulecky: Regulatory Aspects of Na+ Transport in Complex Epithelia (Frog Skin). Am. J. Physiol. 245:R272-280 (1983).

Mikulecky, D.C., Network Thermodynamics in Biology and Ecology: An Introduction,in Ecosystem theory for biological oceanography (R. E. Ulanowicz and T. Platt eds.) Canadian Bull. Fisheries & Aquatic Sci. 231:163-175,1985.

Huf, E.G. and D.C. Mikulecky, Compartmental Analysis of the Na+ Flux Ratio with Application to Data on Frog Skin Epidermis J. theor. Bio. 112:193-220, 1984.

Huf, E.G. and D.C . Mikulecky, Topology as a Controlling factor in the Bioenergetics of Na+ Transport in Complex Epithelia. Am. J. Physiol. 250:F1107-F1118, 1986.

Mintz, E, S.R. Thomas and D.C. Mikulecky, Exploration of Apical Sodium Transport Mechanisms in an Epithelial Model by Network Thermodynamic Simulation of the Effect of Mucosal Sodium Depletion: I. Comparison of Three Different Apical Sodium Permeability Mechanisms and II. An Apical Sodium Channel and Amiloride Blocking. J.Theor. Biol. 123:1-19, 21-34 (1986).

Fidelman, M.L. and D.C. Mikulecky, Network Thermodynamic Modeling of Hormone Regulation of Active Na+ Transport in a Cultured Renal Epithelium (A6) Am. J. Physiol.250:C978-C991 (1986).

Thakker, K.M. and D.C. Mikulecky. Modeling and Simulation of the Nonlinear Dose- Plasma Concentration Response of Phenylbutazone on Periodic Multiple Oral Dosing: A Mechanistic Approach. Mathematical Modelling, 7:1181-1186 (1986).

Fidelman, M.L. and D.C. Mikulecky (1988) Network Thermodynamic Model of Isotonic Solute-coupled Volume Flow in Leaky Epithelium. J. Theor. Biol. 130:73-93.

Mikulecky, D. C. (1990) Modeling intestinal absorption and other nutrition related processes using PSPICE and STELLA. J. Ped. Gastroent. and Nut. 11:7-20.

Seither, R. L., D. F. Trent, D. C. Mikulecky, T. J. Rape and I. D. Goldman (1989) Folate- Pool Interconversions and Inhibition of Biosynthetic Processes after Exposure of L1210 Leukemia Cells to Antifolates, J. Biol. Chem. 264: 17016-17023.

Seither, R. L., D. Hearne, D. Trent, D. C. Mikulecky and I. D. Goldman (1990) SPICE2 network thermodynamic simulation of antifolate effects on purine and pyrimadine biosynthesis: exploring the role of tetrahydrofolate cofactor depletion versus dihydrofolate feedback inhibition, Computers Math. Applic. 20:87-101.

Mikulecky, D.C.(1991) Network Thermodynamics:A Unifying Approach to the Description of Dynamic, Nonlinear, Living Systems in Network Approaches to Ecosystems Theory (J. Burns and I. Hagashi, eds) Cambridge Univ. Press, pp71-100.

Seither, R. L., D. F. Trent, D. C. Mikulecky, T. J. Rape and I. D. Goldman (1991) Effect of Direct Suppression of Thymidylate Synthetase at the 5,10-Methylenetetrahydrofolate Binding Site on the Interconversion of Tetrahydrofolate Cofactors to Dihydrofolate by Antifolates, J. Biol. Chem. 266:4112-4118.

Walz, D.S., S. R. Caplan, D. R. L. Scriven and D. C. Mikulecky (1995) Methods of mathematical modeling in Bioelectrochemistry: General Introduction, in Bioelectrochemistry: Principles and Practice (S. R. Caplan, I. R. Miller, eds.) Birkhauser, Basel.

Mikulecky, D. C. and M. Thellier (1993) Determining the transient kinetic behavior of complex multi-enzyme systems by use of network thermodynamics, C. R. Acad. Sci. Paris, Life Sciences 316: 1399-403.

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