Application of Network Thermodynamics to Problems in Biomedical Engineering

D. C. Mikulecky


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Seither, R. L., D. F. Trent, D. C. Mikulecky, T. J. Rape and I. D. Goldman (1989) Folate-Pool Interconversions and Inhibition of Biosynthetic Processes after Exposure of L1210 Leukemia Cells to Antifolates, J. Biol. Chem. 264: 17016-17023.

Seither, R. L., D. Hearne, D. Trent, D. C. Mikulecky and I. D. Goldman (1990) SPICE2 network thermodynamic simulation of antifolate effects on purine and pyrimadine biosynthesis: exploring the role of tetrahydrofolate cofactor depletion versus dihydrofolate feedback inhibition, Computers Math. Applic. 20:87-101.

Seither, R. L., D. F. Trent, D. C. Mikulecky, T. J. Rape and I. D. Goldman (1991) Effect of Direct Suppression of Thymidylate Synthetase at the 5,10-Methylenetetrahydrofolate Binding Site on the Interconversion of Tetrahydrofolate Cofactors to Dihydrofolate by Antifolates, J. Biol. Chem. 266:4112-4118.

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Thakker, K. M., J. H. Wood and D. C. Mikulecky (1982) Dynamic Simulation of Pharmacokinetic Systems Using the Electrical Circuit Analysis Program SPICE2. Comp. Prog. Biomed. 15:61- 72.

Thakker, K. M. and D. C. Mikulecky (1985) Modelling and Simulation of the Nonlinear Dose-Plasma Concentration Response of Phenylbutazone on Periodic Multiple Oral Dosing: A Mechanistic Approach. Mathematical Modelling, 7:1181-1186(1986).

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Thomas S. R. and Mikulecky D. C. (1978) A network theromodynamic model of salt and water flow across the kidney proximal tubule, Am. J. Physiol. 235: F638-F648.

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Walz, D. (1990) Biothermokinetics of Processes and Energy Conversion, Biochim. Biophys. Acta 1019: 171-224.

Walz, D., S. R. Caplan, D. R. L. Scriven and D. C. Mikulecky (1992) Methods of Bioelectrochemical Modelling, in Treatise on Bioelectrochemistry, (G. Millazzo, ed.) Birkhauser, (in press).

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White J. C. (1979) Reversal of methotrexate binding to dihydrofolate reductase by dihydrofolate : Studies with pure enzyme and computer modeling using network thermodynamics, J. Biol. Chem. 254:10889-10895.

White J. C. and Mikulecky D. C. (1981) Application of network thermodynamics to the computer modeling of the pharmacology of anticancer agents: A network model for methotrexate action as a comprehensive example, Pharmacol. Ther. 15: 251-291.

White, J. C. (1986) Use of the Circuit Simulation Program SPICE2 for Analysis of the Metabolism of Anticancer Drugs, Bull Math. Biol. 48: 353-380.

Wyatt, J. L. (1978) Network Representation of Reaction-diffusion Systems Far From Equilibrium, Comp. Prog. Biomed. 8: 180-195.

Wyatt J.L., Mikulecky D. C. and De Simone J. A. (1980) Network modeling of reaction-diffusion systems and their numerical solutions using SPICE, Chem. Eng. Sci. 35: 2115-2128.

Yates, F. E. (1987) Self Organizing Systems: The Emergence of Order, Plenum Press, N. Y.

Yates, F. E. (1992) Order, Complexity, and Self-Organization in Dynamic Systems: Outline of a Generalized Mechanics for Biology, in Advances in Mathematics and Computers in Medicine vol. 6: (D. C. Mikulecky and M. Witten, eds.), Pergamon Press, (in press).

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