William A. Jiranek, M.D. Professor of Orthopaedic Surgery, Virginia Commonwealth University wjiranek@mcvh-vcu.edu

Education:

• B.A., History, Princeton University (1981)
• M.D., Medicine, University of Virginia (1985)
• Internship, Surgery, Union Memorial Hospital (1986)
• Residency, Orthopaedic Surgery, Tufts University (1990)

Honors and Awards:

• American Orthopaedic Association - Zimmer Travel Award for Research (1992)

Society Memberships:

• Orthopaedic Research Society
• American Society for Biomaterials
• American Academy of Orthopaedic Surgeons

Selected Publications:

Riddle DL, Kong X, Jiranek WA: Two-year incidence and predictors of future knee arthroplasty in persons with symptomatic knee osteoarthritis: Preliminary analysis of longitudinal data from the osteoarthritis initiative. Knee. May 4, 2009. [Epub ahead of print]

Sambandam SN, Hull J, Jiranek WA: Factors predicting the failure of Bernese periacetabular osteotomy: a meta-regression analysis. Int Orthop. Aug 22., 2008. [Epub ahead of print]

Ramage SC, Urban NH, Jiranek WA, Maiti A, Beckman MJ: Expression of RANKL in osteolytic membranes: association with fibroblastic cell markers. Journal of Bone and Joint Surgery American, 89(4):841-848, 2007.

Liacouras PC, Owen JR, Jiranek WA, Wayne JS: Evaluating the mechanical and polymerization characteristics of a modified bone cement. Journal of Arthroplasty, 21(4):606-611, 2006.

Jiranek WA, Hanssen AD, Greenwald AS: Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement. J Bone Joint Surg Am. Nov;88(11):2487-500. Review, 2006.

Qiu J-Y, Beckman MJ, Qian J, Jiranek WA: Simultaneous labeling of mast cell proteases and protease mRNAs at the bone-implant interface of aseptically loosened hip implants. J. Orthopaedic Surgery, 23:942-948, 2005.

Noble AR, Branham DB, Willis MC, Owen JR, Cramer BW, Wayne JS, Jiranek WA: Mechanical effects of the extended trochanteric osteotomy.  Journal of Bone and Joint Surgery, 87:521-529, 2005.

Caldwell PE, Bohlen BA, Owen JR, Brown MH, Harris B, Wayne JS, Jiranek WA: Dynamic confirmation of fixation techniques of the tibial tubercle osteotomy. Clinical Orthopaedics and Related Research, Jul;(424):173-179, 2004.

Dalury DF, Jiranek WA: The incidence of heterotopic ossification after total knee arthroplasty. Journal of Arthroplasty, 19(4):447-452, 2004.

Jiranek WA, Whiddon DR, Johnstone WT:  Late loosening of press-fit cementless acetabular components. Clinical Orthopaedics & Related Research, (418):172-178, 2004. Erratum in: Clin Orthop. Mar;(420):174, 2004.

Mendes MW, Caldwell P, Jiranek WA:  The results of tibial tubercle osteotomy for revision total knee arthroplasty. Journal of Arthroplasty, 19(2):167-174, 2004.

Jiranek WA: Acetabular liner fixation by cement. Clinical Orthopaedics & Related Research, (417):217-223, 2003. Review.

Dalury DF, Jiranek W, Pierson J, Pearson SE: The long-term outcome of total knee patients with moderate loss of motion. Journal of Knee Surgery, 16(4):215-220, 2003.

Sluss JR, Liberti JP, Jiranek WA, Wayne JS, Zuelzer WA: pN collagen type III within tendon grafts used for anterior cruciate ligament reconstruction. Journal of Orthopaedic Research, 19(5):852-857, 2001.

Davis K, Caldwell P, Wayne JS, Jiranek WA: A mechanical comparison of fixation techniques for the tibial tubercle osteotomy.  Clinical Orthopaedics and Related Research, 380:241-249, 2000.

Yin C, Wayne JS, Jiranek WA, Zuelzer WA: Differences in mRNA expression patterns between patellar tendons and anterior cruciate ligaments of immature pigs. Journal of Orthopaedic Research, 17(6):823-828, 1999.

Dalury DF, Jiranek WA: A comparison of the midvastus and paramedian approaches for total knee arthroplasty. Journal of Arthroplasty, 14(1):33-37, 1999.

Yin C, Jiranek WA, Vaughan P, Cardea JA: Differential messenger ribonucleic acid expression in aggressive versus linear periprosthetic osteolysis. Clinical Orthopaedics and Related Research, 352:95-104, 1998.

Lassus J, Salo J, Jiranek WA, Santavirta S, Nevalainen J, Matucci-Cerinic M, Horak P, Konttinen Y: Macrophage activation results in bone resorption. Clinical Orthopaedics and Related Research, 352:7-15. Review, 1998.

Yin C, Wayne JS, Jiranek WA, Zuelzer WA: Biochemical and molecular homogeneity in the patellar tendon of the immature pig. Journal of Orthopaedic Research, 15(5):712-718, 1997.

Bal BS, Jiranek WA, Jasty M, Harris WH: Periprosthetic femoral osteolysis around an uncemented nonmodular Moore prosthesis. Journal of Arthroplasty, 12(3):346-934, 1997.

Konttinen YT, Waris V, Xu JW, Jiranek WA, Sorsa T, Virtanen I, Santavirta S: Transforming growth factor-beta 1 and 2 in the synovial-like interface membrane between implant and bone in loosening of total hip arthroplasty. Journal of Rheumatology. 24(4):694-701, 1997.

Jiranek W, Jasty M, Wang JT, Bragdon C, Wolfe H, Goldberg M, Harris W: Tissue response to particulate polymethylmethacrylate in mice with various immune deficiencies. Journal of Bone and Joint Surgery American, 77(11):1650-1661, 1995.

Alman BA, Naber SP, Terek RM, Jiranek WA, Goldberg MJ, Wolfe HJ: Platelet-derived growth factor in fibrous musculoskeletal disorders: a study of pathologic tissue sections and in vitro primary cell cultures. Journal of Orthopaedic Research, 13(1):67-77, 1995.

Terek RM, Jiranek WA, Goldberg MJ, Wolfe HJ, Alman BA: The expression of platelet-derived growth-factor gene in Dupuytren contracture. Journal of Bone and Joint Surgery American, 77(1):1-9, 1995.

Jasty M, Bragdon C, Jiranek W, Chandler H, Maloney W, Harris WH: Etiology of osteolysis around porous-coated cementless total hip arthroplasties. Clinical Orthopaedics and Related Research, 308:111-126, 1994.

Buechel FF, Drucker D, Jasty M, Jiranek W, Harris WH: Osteolysis around uncemented acetabular components of cobalt-chrome surface replacement hip arthroplasty. Clinical Orthopaedics and Related Research, 298:202-211, 1994.

Jiranek WA, Machado M, Jasty M, Jevsevar D, Wolfe HJ, Goldring SR, Goldberg MJ, Harris WH: Production of cytokines around loosened cemented acetabular  omponents. Analysis with immunohistochemical techniques and in situ  hybridization. Journal of Bone and Joint Surgery American, 75(6):863-879, 1993.

Jasty M, Jiranek W, Harris WH: Acrylic fragmentation in total hip replacements and its biological consequences. Clinical Orthopaedics and Related Research, 285:116-128, 1992.

Jiranek WA, Ruby LK, Millender LB, Bankoff MS, Newberg AH: Long-term results after Russe bone-grafting: the effect of malunion of the scaphoid. Journal of Bone and Joint Surgery American, 74(8):1217-1228, 1992.

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Last update: July 2009