BNFO 301 
Introduction to Bioinformatics
Topic: Genome Analysis
Spring 2013 

Rationale

Information is not knowledge
-- Attributed to Albert Einstein (but no evident source)

Genomic sequencing has produced in recent times an overwhelming amount of information. Actually, the information was always there, contained in DNA. Now it is also contained within computers. Is this an advance? It is, but only in that digization of genetic information facilitates analysis, which can lead to insights into how our world works. Without effective analysis, we are no better off than before genomes were sequenced.

Readings, Tours, and Investigations

    Notes: Search for FMRP in Drosophila

    Notes: What is a Gene (Part II): Companion to Shine J & Dalgarno L (1975). Nature 254:34-38.

    Reading and Tour:
        Comparative genomics of the mycobacteriophages: Insights into bacteriophage evolution.
        Hatfull GF, Cresawn SG, Hendrix RW (2008). Research in Microbiology 159:332-339.
        Tour: Part I and Part II

    Reading and Tour:
        In silico analysis of mycobacteriophage Che12 genome: Characterization of genes
        required to lysogenise Mycobacterium tuberculosis.
        Gomathi NS, Sameer H, Kumar V, Balaji S, Azger Dustackeer VN, Narayana PR (2007).
        Computational Biology and Chemistry 31:82-91. (+ tour)

Problem Set
    Problem Set 5: Blast

To Hand In
    Feb 18: Problem Set 5