BNFO 301 
Introduction to Bioinformatics
Questionnaire on Tour of Madsen et al (1999)
(please press SUBMIT button when finished)
(and please don't use quotation marks in your answers. They break the questionnaire program!)
Spring 2012 

I. Basic Information

A. Your name 
II. Lifestyles of bacteriophage and regulation
  1. Do you understand how CI and Cro proteins and specific DNA sequences lay at the basis of a molecular machine to dirct lambda towards either the lysogenic or lytic pathways?
  2. Any other issues concerning bacteriophage and regulation that warrent discussion?
     
III. Madsen et al (1999)
  1. Did you have any trouble obtaining the article?
  2. Do you have an idea how to assess whether an article might be useful in answering your specific question?
  3. Do you feel comfortable in interpretting Figure 1?
  4. Do you understand the significance of beta-galactosidase activity measurements?
  5. Do you feel comfortable in interpretting Figure 3?
  6. Do you understand the principle behind primer extension experiments?
  7. Were you able to find the sequence between ORF4 and ORF5 in the genome sequence of TP901-1?
  8. Are you able to argue persuasively based on experimental data and your own observations whether ORF4 is or is not a general repressor of lytic function?
  9. Anything other issues related to the article?
     

Do you have any favorite study questions you think need discussion?  

IV. Problem Sets II (Mol Biol Investigations) and III (Genome Sequencing)
  1. Are you comfortable completing Problem Set III, Problem 2?
    If not, you might want to acquaint yourself with a presentation on probability (see Feb 8).
  2. Any other issues arising from going through these problem sets?
     
V. Miscellaneous
Any miscellaneous comments, questions, suggestions, concerns?
     

Thanks!

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