Biocontrol is a clinical development stage biotechnology company that is focused on the anti-infective space. Its primary focus is the development of bacteriophages to treat Gram Negative bacterial infections, such as Pseudomonas aeruginosa, which is the leading cause of death among people with Cystic Fibrosis. Biocontrol is seeking to develop a range of therapeutic products for the treatment of very highly resistant bacterial infections. For more information, the website is: http://www.Biocontrol-ltd.com.
Antibiotic-resistant bacterial infections are a large and growing problem in the global healthcare market costing in excess of $20 billion per annum. The use and overuse of antibiotics has promoted the development of both Gram positive and Gram negative bacterial strains that compromise patient health and can complicate the treatment of other conditions, particularly among hospitalized patients. The increased costs of developing new antibiotics combined with the speed with which resistance develops demands that new and innovative therapeutic approaches be developed.
Bacteriophages are naturally-occurring viruses that are highly specific in killing bacteria, and when selected appropriately, are extremely safe and effective as they do not infect eukaryotic cells or beneficial ("good") bacteria. In addition, the self-replicating nature of a virus means that the dosage levels may initially be very low, and scale up in the presence of infection until the infection is cleared either by the bacteriophage or in concert with the body's own immune defenses.
Biocontrol is, to date, the only company in the world to have completed a Phase 2 clinical trial demonstrating the efficacy of bacteriophages in the treatment of serious bacterial infections: specifically, the treatment of Pseudomonas aeruginosa in chronic adult inflammation or infection of the ear (otitis). Biocontrol is developing products to treat other Pseudomonas infections, including lung infections among cystic fibrosis patients, where Pseudomonas aeruginosa is the leading cause of death among that patient population. Biocontrol is also exploring other potential applications for its bacteriophage technology.