BNFO 300 
Molecular Biology Through Discovery
Questionnaire on Sanger & Tuppy (1951)
(please press SUBMIT button when finished)
Spring 2017  


I. Basic Information

Your name 
II. Old business (no need to repeat anything you've said in a previous questionnaire)
  1. Research Proposal
    Any concerns you'd like to raise concerning your efforts to make progress on your research proposal?
    On track to submit a progress report by the end of Friday?

     
  2. Sanger & Tuppy (1953) - Sections I to III
    Anything further you'd like to discuss regarding the article Sanger & Tuppy (1953) and its companion (Sections I to III)?
    Do you have the article by Sanger & Tuppy in hand? You're sure it's the right one?
    Do you understand what alternative models of protein structure Sanger & Tuppy hoped to distinguish?
    Do you understand how paper chromatography (see presentation) can be used to separate peptides and identify amino acid?
    Do you understand what the paper chromatogram figures in the article signify?
III. Sanger & Tuppy (1951)
  1. How far have you gotten in a productive reading of the article (not just the companion)?
    You can answer by referring to the last section you read or the last study question you addressed (e.g. SQ12) in the companion.

     
  2. Consider how comfortable you are with the following topics (as defined by the companion to Sanger and Tuppy):
    • The overall strategy Sanger & Tuppy used to determine the sequence of insulin
    • The relationship between the figures and tables in Sanger & Tuppy (1951)
    • How the identity of amino acids in chromatogram spots is determined
    • How the order of aminio acids in a a peptide is determined
    • How to use this information to deduce the sequence of insulin
    • Any study question

    With this in mind, and any other concerns that arise in your mind, how could class time best be spent to meet your needs?
    As always, refer to specific matters and relate your current understanding and efforts you've made to address your discomfort.

IV. Problem Set 1, Problem 1 (community effort)
Have you looked over Problem Set 1, Problem 7 and recognize it as a replay of Sanger & Tuppy (1953)?
Have you looked over the effort to organize the class into groups to answer Problem Set 1, Problem 7?
Do you foresee any problems in accomplishing the task?
V. Miscellaneous
Any other comments, questions, suggestions, or concerns you may have?

Thanks!

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