BNFO 300 
Molecular Biology Through Discovery
Questionnaire on notes: Belozersky & Spirin (1957) preceding the discovery of mRNA
(please press SUBMIT button when finished)
Fall 2013 


I. Basic Information

A. Your name 
II. Old business -- Crick et al (1961) General Nature of the Genetic Code

A. How far have you gotten in Crick et al (1961) (and its companion)? The simulation?
     

Consider how comfortable you are with the following topics regarding Crick et al (1961):

B. The prediction of the loop code shown in Fig. 2 of the companion

C. Mutagenesis by acridines

D. Recombination between two phages

E. The nature of suppressor mutations as relevant to Crick et al (1961)

F. How to construct new mutant T4 phages

G. What the double and triple mutants say about the genetic code
     

Choose up to five study questions that you would most like discussed in class:

SQ1  SQ2 SQ3 SQ4 SQ5 SQ6 SQ7  SQ8  SQ9 
SQ10 SQ11 SQ12 SQ13  SQ14 SQ15 SQ16 SQ17 
SQ18  SQ19 SQ20 SQ21 SQ22 SQ23 SQ24 
III. Old business -- Jones & Nirenberg (1962) Survey of RNA codewords

A. How far have you gotten in Jones & Nirenberg (1962) (and its companion)? The Alien Genetic Code simulation?
     

Consider how comfortable you are with the following topics regarding these matters:

B. The overall goal of the work by Nirenberg and others

C. The specific focus of Jones & Nirenberg (1961)

D. The nature of the experiment

E. The nature of RNA produced by polynucleotide phosphorylase

F. Theoretical expectations of experiment J108, Table 3

G. Interpretation of Table 3

H. How to deduce the alien genetic code
     

Choose up to four study questions that you would most like discussed in class:

SQ1  SQ2 SQ3 SQ4 SQ5 SQ6 SQ7  SQ8  SQ9 
SQ10 SQ11 SQ12 SQ13  SQ14 SQ15 SQ16 
IV. Belozersky & Spirin (1957)

A. How far have you gotten in this article (and its companion)?
     

Consider how comfortable you are with the following topics regarding these matters:

B. The one-gene - one-ribosome - one-protein model (Fig. 2 of the companion)

C. Volkin and Astrachan's result

D. How to read the table of Belozersky & Spirin

E. How to calculate (G+T) / (A+C) etc

F. The relationship of Belozersky & Spirin's results to the 1-gene 1-ribosome 1-protein model
     

Choose up to three questions that you would most like discussed in class:

SQ1  SQ2 SQ3 SQ4 SQ5 SQ6 SQ7  Scenario 1  Scenario 2 
V. Miscellaneous

Any other comments, questions, suggestions, or concerns you may have?

Thanks!

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