12 Jan The Nature of Mutation

Luria SE, Delbrück M (1943). Mutations of bacteria from virus sensitivity to virus resistance. Genetics 28:491-511.

Cairns J, Overbaugh J, Miller S (1988). The origin of mutants. Nature 335:142-145.

23 Jan The Fine Structure of the Gene (Unit 1)

*Benzer S (1959). On the topology of the genetic fine structure. Proc Natl Acad Sci 45:1607-1620. (Unit 1, p.41)

Benzer S (1961). On the topography of the genetic fine structure. Proc Natl Acad Scie 47:403-415. (Unit 1, p.18)

30 Jan Genetic Regulatory Mechanisms (Unit 6)

*Pardee AB, Jacob F, Monod J (1959). The genetic control and cytoplasmic expression of "inducibility" in the synthesis of ß-galactosidase by E. coli. J Mol Biol 1:165-178.

Jacob F, Monod J (1961). Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol 3:318-356. (Unit 6, p.192)

4 Feb Conjugation and Genetic Recombination (Unit 5)

*Hayes W (1953). Observations on a transmissible agent determining sexual differentiation in Bacterium coli. J Gen Microbiol 8:72-88. (Unit 5, p.161)

Wollman E-L, Jacob F, Hayes W (1956). Conj[ugation and genetic recombination in Escherichia coli K-12. Cold Spring Harbor Symp Quant Biol 21:141-162. (Unit 5, p.138)

9 Feb The Search for Colinearity (Unit 4)

*Yanofsky C, Carlton BC, Guest JR, Helinski DR, Henning U (1964). On the colinearity of gene structure and protein structure. Proc Natl Acad Sci 51:266-272. (Unit 4, p.117)

Sarabhai AS, Stretton AOW, Brenner S, Bolle A (1964). Co-linearity of the gene with the polypeptide chain. Nature 201:13-17. (Unit 4, p.127)

First Presentations

2 Mar EXAM 1 (take home)

4 Mar The Nature of the Genetic Code (Unit 2)

*Crick FHC, Barnett L, Brenner S, Watts-Tobin RJ (1961). General nature of the genetic code for proteins. Nature 192:1227-1232. (Unit 2, 64)

Supplemental readings in Unit 2

9-13 Mar ============ MIDTERM BREAK ============

17 Mar The Nature of the Genetic Code (Unit 2 cont)

24 Mar Identification of Messenger RNA

*Brenner S, Jacob F, Meselson M (1961). An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Nature 190:576-581.

31 Mar Decoding the amber and ochre Triplets (Unit 3)

*Brenner S, Stretton AOW, Kaplan S (1965). Genetic code: The `nonsense' triplets for chain termination and their suppression. Nature 206:994-998. (Unit 3, p.101)

7 Apr Structure-Function Relationships in Proteins (Unit 8)

*Perutz MF, Kendrew JC, Watson HC (1965). Structure and function of haemoglobin: II. Some relations between polypeptide chain configuration and amino acid sequence. J Mol Biol 13:669-678. (Unit 8, p.291)

Perutz MF, Lehmann H (1968). Molecular pathology of human haemoglobin. Nature 219:902-909. (Unit 8, p.301)

Second Presentations

27 Apr EXAM 2 (take home)

*Primary papers to be discussed