Biol 591 
Introduction to Bioinformatics
Scenarios
Fall 2003 
Comparison of genomes to look for genes responsible for pathogenesis

We have two slightly different pathogenic strains of E. coli, O157:H7 EDL933  and O157:H7 Sakai, to compare against the nonpathogenic strain K-12. To make sure that each comparison is well represented, I've divided us as follows:
 
Person Organism to consider (besides K-12) Related article
Kokila Amara E. coli O157:H7 EDL933  Perna et al, 2001
Jen Fettweis E. coli O157:H7 EDL933 Perna et al, 2001
Brett Kliner E. coli O157:H7 Sakai  Hayashi et al, 2001
James Mastros E. coli O157:H7 EDL933 Perna et al, 2001
Anne Morris E. coli O157:H7 EDL933 Perna et al, 2001
Sheila Panyam E. coli O157:H7 Sakai Hayashi et al, 2001
Manish Patel E. coli O157:H7 EDL933 Perna et al, 2001
Calvin Smith E. coli O157:H7 Sakai Hayashi et al, 2001
Scott Taylor E. coli O157:H7 Sakai Hayashi et al, 2001
Yue Zhao E. coli O157:H7 Sakai Hayashi et al, 2001

Please read the article related to your particular pathogenic strain (if you haven't done so already), download the set of deduced proteins of both E. coli K-12 your pathogenic strain (by Monday, 8 Sep), and Blast the two sets against each other (by Monday, 8 Sep).