Scientific story (html)
In brief: You are looking for the biochemical weak point in the defenses of a deadly parasite. You know the rates at which the enzymes of a pathway operate. How do you translate this information into a computer model that can predict the effect of hypothetical drugs?Bioinformatic tools
Metabolic modelingPresentation - Biological example of a metabolic model (ppt)
Homegrown programs to illustrate how metabolic models are made and modified.
ADP-As(Homegrown version)Perl focus: Array operations..A simple molecular model of the spontaneous breakdown of ADP-AsO4, a derivative of ADP formed during treatment of patients with arsinicals (once used in treating sleeping sickness).glycolysis(Homegrown version)A model of the reactions of glycolysis, including the transport of glucose into the cell and the export of pyruvate.
Problem Set - Just one for this scenario (html)