Biol 591 
Introduction to Bioinformatics
Scenarios
Fall 2002 
Identification of a possible regulatory site in genomic DNA

Scientific story (html)

In brief: You find by chance a sequence upstream from an interesting gene that looks suspiciously like a regulatory sequence. How can you assess the likelihood of your find?
Bioinformatic tools
Simple simulation
     Make up random sequences. Count how many times a regulatory sequence arises.
Pattern recognition
     Scan entire genome, counting sequences that satisfy criteria for regulatory sequence.
Notes - Molecular biology  (PDF) (Questions)
Notes - Programming (html) (Questions)

Programs

Simple simulation: Dice roll (PL)
     A model program just to get across the idea of a simulation.
Simple simulation/Pattern recognition: Sequence search in random sequence
     The concept will be discussed, but we won't actually write such a program
Pattern recognition: Sequence search in whole genome (PL)
Perl focus: Simple pattern matching.

Problem Set - Molecular biology (PDF)
Problem Set - Programming (PDF)