Biol 591 
Introduction to Bioinformatics
Scenarios
Fall 2002 
Comparison of genomes to look for genes responsible for pathogenesis

We have two slightly different pathogenic strains of E. coli, O157:H7 EDL933  and O157:H7 Sakai, to compare against the nonpathogenic strain K-12. To make sure that each comparison is well represented, I've divided us as follows:
 
Person Organism to consider (besides K-12) Related article
Aman Bajwa E. coli O157:H7 EDL933  Perna et al, 2001
Henry Bateman E. coli O157:H7 EDL933 Perna et al, 2001
Tommy Bills E. coli O157:H7 Sakai  Hayashi et al, 2001
Andrew Boutoun E. coli O157:H7 EDL933 Perna et al, 2001
Hey Chong E. coli O157:H7 EDL933 Perna et al, 2001
Leslie Filicky E. coli O157:H7 EDL933 Perna et al, 2001
Steve Killeffer E. coli O157:H7 Sakai Hayashi et al, 2001
Andrey Matveyev E. coli O157:H7 EDL933 Perna et al, 2001
Antoine Nicolas E. coli O157:H7 Sakai Hayashi et al, 2001
Jigar Patel E. coli O157:H7 Sakai Hayashi et al, 2001
Daniella Puiu E. coli O157:H7 Sakai Hayashi et al, 2001
Xinguo Qian E. coli O157:H7 Sakai Hayashi et al, 2001
Carlos Ramirez E. coli O157:H7 Sakai Hayashi et al, 2001
Larry Schwartz E. coli O157:H7 EDL933 Perna et al, 2001

Please read the article related to your particular pathogenic strain (skim by Friday, 13 Sep), download the set of deduced proteins of both E. coli K-12 your pathogenic strain (by Monday, 16 Sep), and Blast the two sets against each other (by Monday, 16 Sep).