My research interests include the role of exogenous and endogenous cannabinoids, as well as inhibiting fatty acid amide hydrolase (FAAH), in pain, inflammation, and memory processes.
Selected Publications | Pubmed
Varvel SA, Wise LE, Lichtman AH. (2009). Are CB1 Receptor Antagonists Nootropic or Cognitive Impairing Agents. Drug Development Research, 69:1-11.
Wise LE, Harloe JP, Lichtman AH. (2009). Fatty Acid Amide Hydrolase (FAAH) Knockout Mice Exhibit Enhanced Acquisition of an Aversive, but not of an Appetitive, Barnes Maze Task. Neurobiol Learn Mem.
Wise LE, Thorpe AJ, Lichtman AH. (2009). Hippocampal CB 1 receptors mediate the memory impairing effects of delta 9 -tetrahydrocannabinol. Neuropsychopharmacology, In press .
Vann RE, Wise LE, Varvel SA, Philibin SD, Walentiny DM, Porter JH . (2009). Route of administration influences substitution patterns in rats trained to discriminate methadone versus vehicle. Drug and Alcohol Dependence. 103(3):124-30.
Wise LE, Iredale PA, Lichtman AH. (2008). The cannabinoid CB(1) receptor antagonist CE prolongs spatial memory duration in a rat delayed radial arm maze memory task. Eur J Pharmacol. 590(1-3):246-9.
Wise LE, Cannavacciulo R, Cravatt BF, Martin BR, Lichtman AH. (2008) Evaluation of fatty acid amides in the carrageenan-induced paw edema model. Neuropharmacology, 54(1); 181-8.
Wise LE, Lichtman AH. (2007) The uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist memantine prolongs spatial memory in a rat delayed radial arm maze memory task. European Journal of Pharmacology, Dec 1; 575 (1-3); 98-102.
Wise LE, Iredale PA, Stokes R, Lichtman AH. (2007) Combination of rimonabant and donepezil prolongs spatial memory duration. Neuropsychopharmacology, 32(8); 1805-12.
Wise LE, Shelton CC, Cravatt BF, Martin BR, Lichtman AH. (2007) Assessment of anandamide’s pharmacological effects in mice deficient of fatty acid amide hydrolase (FAAH) and CB1 receptors. European Journal of Pharmacology 557(1); 44-8.
Varvel SA, Wise LE, Niyuhire F, Cravatt BF, Lichtman AH. (2007) Inhibition of FAAH accelerates acquisition and extinction rates in a spatial memory task. Neuropsychopharmacology, 32(5); 1032-41.
Varvel SA, Anum E, Niyuhire F, Wise LE, Lichtman AH. (2005) Delta9 THC-induced cognitive deficits are reversed by the GABAA antagonist bicuculline. Psychopharmacology, 178(2-3); 317-27.
Copyright © 2007-2011 Aron H.
Lichtman, Ph.D. All Rights Reserved.